+ Site Statistics
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

A case of T-cell prolymphocytic leukemia

A case of T-cell prolymphocytic leukemia

Japanese Journal of Clinical Hematology 33(6): 817-822

A 54-year-old man who had been known to have a high prolymphocyte count for four years was admitted to our hospital because of dyspnea in September, 1990. Physical examination revealed skin eruption, lymphadenopathy and hepatosplenomegaly. Chest X-ray demonstrated bilateral pleural effusions. The leukocyte count was 232,900/microliter with 99% lymphoid cells possessing single nucleoli. The cells expressed the phenotype CD2+, CD3-, CD4+, CD7+, and CD8-. Southern blot analysis of DNA from these cells revealed monoclonal rearrangement of T-cell receptor beta-chain genes. Anti-human T-cell lymphotropic virus type 1 (HTLV-1) antibody and HTLV-1 proviral DNA were not detected. A biopsy specimen from the skin lesions showed infiltration of the leukemic cells which were positive for anti-MT1 antibody. Histological finding of the axillary lymph node was malignant lymphoma, diffuse, medium-sized, T-cell type. Combination chemotherapy resulted in the improvement of skin eruption, lymphadenopathy, hepatosplenomegaly and pleural effusions, although his prolymphocyte count increased to 910,000/microliters. He died of cerebral bleeding in July, 1991. We diagnosed this case as T-cell prolymphocytic leukemia, observed for five years.

(PDF emailed within 1 workday: $29.90)

Accession: 039031233

Download citation: RISBibTeXText

PMID: 1433923

Related references

A case report of T cell prolymphocytic leukemia and Kaposi sarcoma and a review of T cell prolymphocytic leukemia. Acta Haematologica 127(4): 235-243, 2012

A new case of S├ęzary cell leukemia: a morphological variant of prolymphocytic leukemia. Haematologica 85(7): 775-776, 2000

Cytogenetic studies on prolymphocytic leukemia. 1. B-cell prolymphocytic leukemia. Hematologic Pathology 1(1): 27-33, 1987

Cytogenetic studies on prolymphocytic leukemia. II. T cell prolymphocytic leukemia. Blood 70(4): 926-931, 1987

Prolymphocytic leukemia or prolymphocytic transformation of mantle cell lymphoma. American Journal of Clinical Pathology 116(5): 781-782, 2001

A case of B-cell prolymphocytic leukemia. Japanese Journal of Clinical Hematology 26(3): 448-454, 1985

A pediatric case of T-cell prolymphocytic leukemia. Pediatric Blood and Cancer 62(6): 1061-1062, 2015

T- cell prolymphocytic leukemia - a rare case. Indian Journal of Cancer 42(2): 104-106, 2005

Case Study Interpretation--Houston: Case 4. T-cell prolymphocytic leukemia. Cytometry. Part B, Clinical Cytometry 80(4): 264-268, 2011

Cytogenetic studies in a case of T-cell prolymphocytic leukemia. Cancer Genetics and Cytogenetics 12(2): 171-174, 1984

A case of T cell prolymphocytic leukemia involving blast transformation. International Journal of Hematology 93(5): 667-672, 2011

T-Cell Prolymphocytic Leukemia in a 14-year-Old patient Case Report. Blood 100(11): Abstract No 4987, November 16, 2002

Prolymphocytic leukemia of T-cell type. Report of a case with autopsy. Japanese Journal of Clinical Hematology 17(9): 989-995, 1976

Unusual lymphoma manifestations: case 3. CD8+ T-cell prolymphocytic leukemia. Journal of Clinical Oncology 22(3): 560-562, 2004

T-cell prolymphocytic leukemia treated with alemtuzumab and followed by autologous hematopoietic stem cell transplantation: a case report. Zhonghua Xue Ye Xue Za Zhi 36(6): 536, 2016