A comparison of the effects of cytosine arabinoside and adenine arabinoside on some aspects of brain growth and development in the rat

Adlard, B.P.; Dobbing, J.; Sands, J.

British Journal of Pharmacology 54(1): 33-39

1975


ISSN/ISBN: 0007-1188
PMID: 1169994
DOI: 10.1111/j.1476-5381.1975.tb07406.x
Accession: 039051339

Download citation:  
Text
  |  
BibTeX
  |  
RIS

Article/Abstract emailed within 0-6 h
Payments are secure & encrypted
Powered by Stripe
Powered by PayPal

Abstract
1. Treatment of pregnant rats with cytosine arabinoside (ara-C, 50 mg/kg, i.p.)at 14 days of gestation severely impaired both prenatal and postnatal whole brain growth in their offspring, although the cerebellum was relatively less affected than whole brain. 2. Rats treated at 5 days of age with ara-C (250 mg/kg, i.p.) showed an impairment in growth of the cerebellum relative to the rest of the brain. 3. Adenine arabinoside (ara-A) treatment, either prenatally or postnatally, had negligible effect on brain growth, even at doses considerably higher than those of ara-C. 4. Adult rats, previously treated with ara-C (50 mg/kg, i.p.) at 14 days of gestation, showed an impairment in discrimination learning when tested in a water T-maze. 5. These results are discussed in relation to the proposed use of ara-C or ara-A as antiviral agents, particularly against intrauterine infection with cytomegalovirus.

A comparison of the effects of cytosine arabinoside and adenine arabinoside on some aspects of brain growth and development in the rat