A controlled therapeutic trial in paucibacillary leprosy comparing a single dose of rifampicin with a single dose of rifampicin followed by one year of daily dapsone. the Collaborative Study Group for the Treatment of Leprosy in Zaire

Pattyn, S.R.; Groenen, G.; Janssens, L.; Kuykens, L.; Mputu, L.B.

Leprosy Review 62(2): 179-185


ISSN/ISBN: 0305-7518
PMID: 1870380
Accession: 039055241

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The cure rates of two treatment regimens in PB leprosy were compared in a prospective randomized trial: treatment U consisting of a single dose of rifampicin 40 mg/K bodyweight, and treatment A of rifampicin 1500 mg in a single dose, followed by one year of daily dapsone 100 mg. In patients with a BI = 0, the cure rates evaluated on the basis of histopathology of skin biopsies, were identical for the two regimens but in patients with a BI = 1, cure and relapse rates were unacceptable. For this reason and particularly the need to separate patients on the basis of the BI in skin biopsies, the single dose regimen does not appear to be suited for wide-scale application.