Section 40
Chapter 39,071

A live vaccine against tick-borne encephalitis: integrated studies. I. Basic properties and behaviour of the E5 "14" Clone (Langat virus)

Mayer, V.

Acta Virologica 19(3): 209-218


ISSN/ISBN: 0001-723X
PMID: 239576
Accession: 039070503

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The course of plaque segregation from the Langat E5 strain of the E5 "14" clone is described. The virus, displaying an ic+ sc s plus or minus t e u s character, reproduced at 35 and 37, but not at 39 degree C. In subcutaneously (sc) inoculated monkeys, viraemia lasted for 2--4 days without detectable central nervous system (CNS) involvement. In sc inoculated 8--10 g mice, the infection was manifested only by a transient trace viraemia, but caused a marked resistance against challenge with virulent tick-borne encephalitis (TE) viruses, protection indices being 5.7--6.7. Pathogenetic investigations in challenged, live virus-immunized mice showed no signs of a marked productive infection except of a booster effect.

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