A specific receptor for retinol binding protein as detected by the binding of human and bovine retinol binding protein to pigment epithelial cells
Heller, M.; Bok, D.
American Journal of Ophthalmology 81(1): 93-97
ISSN/ISBN: 0002-9394 PMID: 943148 DOI: 10.1016/0002-9394(76)90198-7
By means of autoradiographic techniques the specific plasma carrier of retinol, namely retinol binding protein (RBP) in a radioactive form (retinol-125I.RBP), bound specifically in vivo to the choroidal surface of intact, isolated bovine pigment epithelial cells. The retinol-125I.RBP did not bind to the retinal surface of the pigment epithelial cells nor did not bind to photoreceptors. Retinol is normally provided to the retina from the blood via a specific complex formation with a receptor on the chordial surface of the pigment epithelial cells. Retinol metabolism might be deranged in some diseases through a defect in the pigment epithelial receptor for RBP.