Acute effects of alpha-MSH on the rat zona glomerulosa in vivo

Nussdorfer, G.G.; Mazzocchi, G.; Malendowicz, L.K.

Biochemical and Biophysical Research Communications 141(3): 1279-1284


ISSN/ISBN: 0006-291X
PMID: 3028391
DOI: 10.1016/s0006-291x(86)80184-x
Accession: 039174465

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alpha-MSH acutely enhanced the plasma concentration of aldosterone (but not that of corticosterone) in the rat, with a maximal response at a dose of 100 micrograms/kg. This dose of alpha-MSH increased the blood level o aldosterone and the activity of 11 beta-hydroxylase and 18-hydroxylase of capsular adrenals in rats infused for 24 h with dexamethasone, dexamethasone plus ACTH, or captopril plus angiotensin II, but not in animals treated with captopril alone. The plasma concentration of corticosterone and the activity of 11 beta-hydroxylase in the inner adrenal layers were not changed. These findings indicate that alpha-MSH is specifically involved in the acute stimulation of the late steps of the secretory activity of the rat zona glomerulosa, and that this action of alpha-MSH requires a normal level of circulating angiotensin II.