+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Acute radiation-induced pulmonary damage: a clinical study on the response to fractionated radiation therapy

Acute radiation-induced pulmonary damage: a clinical study on the response to fractionated radiation therapy

International Journal of Radiation Oncology, Biology, Physics 13(2): 179-188

Acute radiation-induced pulmonary damage can be a significant cause of morbidity in radiation therapy of the thorax. A prospective, clinical study was conducted to obtain dose-response data on acute pulmonary damage caused by fractionated radiation therapy. The endpoint was a visible increase in lung density within the irradiated volume on a computed tomographic (CT) examination as observed independently by three diagnostic radiologists. Fifty-four patients with various malignancies of the thorax completed the study. CT chest scans were taken before and at preselected times following radiotherapy. To represent different fractionation schedules of equivalent biological effect, the estimated single dose (ED) model, ED = D X N-0.377 X T-0.058 was used in which D was the average lung dose within the high dose region in cGy, N was the number of fractions, and T was the overall treatment time in days. Patients were grouped according to ED and the percent incidence of pulmonary damage for each group was determined. Total average lung doses ranged from 29.8 Gy to 53.6 Gy given in 10 to 30 fractions over a range of 12 to 60 days. Five patient groups with incidence ranging from 30% (ED of 930) to 90% (ED of 1150) were obtained. The resulting dose-response curve predicted a 50% incidence level at an ED value (ED50) of 1000 +/- 40 ED units. This value represents fractionation schedules equivalent to a total average lung dose of 32.9 Gy given in 15 fractions over 19 days. Over the linear portion of the dose-response curve, a 5% increase in ED (or total dose if N and T remain constant), predicts a 12% increase in the incidence of acute radiation-induced pulmonary damage.

Please choose payment method:

(PDF emailed within 0-6 h: $19.90)

Accession: 039180363

Download citation: RISBibTeXText

PMID: 3818385

DOI: 10.1016/0360-3016(87)90125-8

Related references

A clinical study of radiation damage to the human eye following fractionated radiation therapy. International Journal of Radiation Oncology*biology*physics 4(Supp-S1): 24-0, 1978

Comparative evaluation of hydroxyproline in urine and in serum as a possible clinical parameter for radiation-induced destruction of connective tissue due to fractionated radiation therapy. Strahlentherapie 157(6): 412-417, 1981

Radiation-induced DNA damage and repair in lymphocytes of breast cancer patients in comparison with acute skin reactions after radiation therapy. Environmental & Molecular Mutagenesis 39(Suppl. 33): 50, 2002

Safety and Efficacy of Stereotactic Body Radiation Therapy (SBRT) Reirradiation for New or Recurrent Pulmonary Malignancies Following Previous In-Field Conventionally Fractionated Thoracic Radiation Therapy (CFRT). International Journal of Radiation Oncology*biology*physics 90(5): S20-S21, 2014

Effects of acute and fractionated doses of iodine 131 induced radiation damage to mouse spermatogonia. IRCS (International Research Communications System) Medical Science Library Compendium 8(12): 912-913, 1980

Quantitative description of the process of radiation inactivation of cells. 3. Cell recovery from sublethal radiation damage. Fractionated radiation method. Tsitologiia 15(11): 1405-1414, 1973

Radiation therapy-induced mucositis: relationships between fractionated radiation, NF-kappaB, COX-1, and COX-2. Cancer Treatment Reviews 32(8): 645-651, 2006

Treatment of artificially-induced pulmonary metastases with fractionated doses of vincristine and/or radiation therapy. Clinical and Experimental Metastasis 1(1): 71-81, 1983

Response of male germ cells of mouse to acute and fractionated doses of 131I induced radiation. Canadian Journal of Genetics and Cytology. Journal Canadien de Genetique et de Cytologie 24(6): 817-820, 1982

Response of male germ cells of mouse to acute and fractionated doses of iodine 131 induced radiation. Canadian Journal of Genetics & Cytology 24(6): 817-820, 1982

Quantitative effect of combined chemotherapy and fractionated radiotherapy on the incidence of radiation-induced lung damage: A prospective clinical study. International Journal of Radiation Oncology Biology Physics 28(3): 563-574, 1994

Clinical Indicators of Psychosocial Distress Predict for Acute Radiation-Induced Fatigue in Patients Receiving Adjuvant Radiation Therapy for Breast Cancer: An Analysis of Patient-Reported Outcomes. International Journal of Radiation Oncology, Biology, Physics 95(3): 946-955, 2017

Recovery of cells from sublethal radiation damage with fractionated radiation dose. Izvestiia Akademii Nauk Sssr. Seriia Biologicheskaia 2: 221-231, 1971

Pathology of acute radiation sickness induced by relatively proportional combined radiation damage. Arkhiv Patologii 54(11): 10-15, 1992

Contribution of base lesions to radiation-induced clustered DNA damage: implication for models of radiation response. Radiation Research 156(5 Pt 2): 590-593, 2001