+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Adrenoceptor-mediated control of glucose homeostasis in obese hyperglycaemic (ob/ob) mice

Adrenoceptor-mediated control of glucose homeostasis in obese hyperglycaemic (ob/ob) mice

Diabetes Research 14(2): 87-91

Adrenoceptor-mediated control of glucose homeostasis in lean (+/+) and obese hyperglycaemic (ob/ob) mice was investigated by intraperitoneal administration of alpha and beta adrenoceptor agonists and antagonists, and by chemical sympathectomy. In lean mice, beta adrenoceptor stimulation with isoprenaline (50 mumol/kg) transiently raised plasma insulin and lowered plasma glucose, while alpha adrenoceptor stimulation with phenylephrine (50 mumol/kg) transiently lowered plasma insulin and raised plasma glucose. In ob/ob mice the insulin responses to isoprenaline and phenylephrine were similar but more slowly generated and protracted. However in contrast to lean mice, isoprenaline transiently raised plasma glucose and phenylephrine lowered plasma glucose in ob/ob mice. Beta adrenoceptor antagonism with propranolol (100 mumol/kg) produced a more protracted decrease of plasma insulin in ob/ob mice than lean mice, although plasma glucose was not significantly altered in either genotype. Alpha adrenoceptor antagonism with phentolamine (100 mumol/kg) transiently increased plasma insulin and produced a protracted decrease of plasma glucose in both genotypes. Chemical sympathectomy with 6-hydroxydopamine (65 mg/kg ip) temporarily reduced food intake and plasma glucose without affecting plasma insulin in lean mice. In ob/ob mice, chemical sympathectomy produced temporary but marked reductions of food and fluid intake with concomitant reductions in plasma glucose and insulin. Plasma glucose and insulin returned almost to pretreatment values by 7 days, whereas fluid intake rose to above pretreatment amounts and food intake became maintained at the amount consumed by lean mice. Food and fluid intake returned to pretreatment amounts at 4-5 weeks. The results indicate abnormalities of adrenoceptor mechanisms in ob/ob mice which favour impaired glucose homeostasis.

Please choose payment method:

(PDF emailed within 1 workday: $29.90)

Accession: 039193310

Download citation: RISBibTeXText

PMID: 1966872

Related references

Coplanar polychlorinated biphenyls impair glucose homeostasis in lean C57BL/6 mice and mitigate beneficial effects of weight loss on glucose homeostasis in obese mice. Environmental Health Perspectives 121(1): 105-110, 2013

Development of glucose intolerance and impaired plasma insulin response to glucose in obese hyperglycaemic (ob/ob) mice. Hormone and Metabolic Research 13(10): 556-560, 1981

Aberrant Expression of FBXO2 Disrupts Glucose Homeostasis Through Ubiquitin-Mediated Degradation of Insulin Receptor in Obese Mice. Diabetes 66(3): 689-698, 2017

On the origin of hyperglycaemia in the obese-hyperglycaemic mouse (obob): effect of diet on blood glucose and serum insulin in obob and gold-thioglucose obese mice. Diabetologia 7(5): 373-378, 1971

In vitro utilization of uniformly labelled 14C-glucose in the adrenals of normal and obese-hyperglycaemic mice. Acta Endocrinologica 39: 599-604, 1962

Chronic administration of sibutramine reduces plasma glucose levels in obese hyperglycaemic mice. British Journal of Pharmacology 120(PROC Suppl. ): 352P, 1997

Furosemide treatment causes age-dependent glucose intolerance and islet damage in obese-hyperglycaemic mice. Pharmacology & Toxicology. 72(4-5): 304-309, 1993

Effects of pituitary growth hormone on the insulin and hyperglycaemic-glycogenolytic factor extractable from the pancreas of obese-hyperglycaemic mice. Nature 177(4522): 1235, 1956

Glucagon-like peptide-1- amide and glucose-dependent insulinotropic polypeptide in the hyperinsulinaemia of obese hyperglycaemic mice. Proceedings of the Nutrition Society 52(1): 38A, 1993

Transport and metabolism of glucose by the small intestine of lean and obese-hyperglycaemic (ob/ob) mice in vitro: effects of age. Biochemical Society Transactions 8(1): 56, 1980

Histochemical studies on glucose-6-phosphatase, adenosine triphosphatase and amylo phosphorylase in the pancreatic islets of normal and obese-hyperglycaemic mice. Acta Endocrinologica 39: 474-482, 1962

Effect of glucose and gastrointestinal hormones on the accumulation and efflux of cyclic AMP from isolated islets of langerhans of lean and obese hyperglycaemic mice. Journal of Endocrinology 69(3): 26p-26p, 1976

Altered glucose homeostasis in alpha2A-adrenoceptor knockout mice. European Journal of Pharmacology 505(1-3): 243-252, 2004

Diurnal variations of food consumption, plasma glucose and plasma insulin concentrations in lean and obese hyperglycaemic mice. Hormone Research 6(5/6): 380-386, 1975