Adsorption and chromatographic properties of modified silica sorbents for the production of viral preparations
Krasilnikov, I.; Borisova, V.
Journal of Chromatography 446: 211-219
The adsorption and chromatographic properties of modified silica sorbents for application to different viruses have been investigated. Minimal adsorption of viruses was observed on macroporous silicas with hydrophilic properties of the sorbent surface. The universal sorbent for the gel-permeation chromatography of viruses was macroporous silica, chemically modified with polyvinylpyrrolidone (PVP). The viruses were purified on this sorbent without loss of biological activity. Preparative chromatography on PVP-silica was used for virus vaccine production.