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Alpha 1-antitrypsin phenotypes of healthy persons and chronic bronchitis patients



Alpha 1-antitrypsin phenotypes of healthy persons and chronic bronchitis patients



Terapevticheskii Arkhiv 59(9): 112-115



The paper is concerned with phenotyping of alpha 1-antitrypsin using a method of isoelectric focusing in the polyacrylamide gel with ampholine (pH-4-6) in 1000 healthy persons and 583 patients with chronic bronchitis. Phenotype M was registered in 96 and 95.71% of the cases, respectively. The occurrence of heterozygous phenotypes was practically similar among the healthy persons as well as among the patients (4.0 and 4.29%, respectively). It was concluded that the heterozygous carrying of an alpha 1-antitrypsin deficit gene was of no particular importance in the development of chronic bronchitis.

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Accession: 039217921

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PMID: 2962325


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