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Alpha 2-adrenoceptor-mediated inhibition of nerve stimulation-evoked release of neuropeptide y (NPY) -like immunoreactivity in the pithed guinea-pig

Dahlöf, C.; Dahlöf, P.; Lundberg, J.M.

European Journal of Pharmacology 131(2-3): 279-283

1986


ISSN/ISBN: 0014-2999
PMID: 3028832
DOI: 10.1016/0014-2999(86)90583-2
Accession: 039218111

Clonidine (10 micrograms X kg-1) reduced by almost 50% the increase in plasma neuropeptide (NPY)-like immunoreactivity (-LI) induced by preganglionic nerve stimulation at 8 Hz. This effect was reversed by yohimbine (1 mg X kg-1) which caused a three-fold increase of the plasma NPY-LI. Prazosin (1 mg X kg-1) had no such effect. Guanethidine (5 mg X kg-1) reduced the stimulation-evoked increase in plasma NPY-LI. It is concluded that the release of NPY-LI evoked by nerve stimulation from sympathetic nerve terminals is controlled by a presynaptic alpha 2-adrenoceptor-mediated mechanism.

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