+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

An electrophysiological study on the effects of tryptophan and cortisol on schizophrenic and other mentally ill patient groups and on normal subjects



An electrophysiological study on the effects of tryptophan and cortisol on schizophrenic and other mentally ill patient groups and on normal subjects



Biological Psychiatry 11(4): 389-401



Direct current potentials measured on the scalp suprajacent to the midline prefrontal cortex appear to monitor the metabolic activity, via CO2 production, of this portion of the cerebrum. Changes in the frontal potential 90 min after oral administration of 2.0 g L-tryptophan and of 50 mg cortisol were studied in groups of subjects defined by age, sex, psychiatric diagnosis, and medication. Twelve normal males, 10 nonschizophrenic male psychiatric inpatients, and 6 normal females showed a significant decrease in their frontal voltages, most marked in the females, after tryptophan loading. A nonsignificant voltage increase was produced by subsequent administration of cortisol. Tryptophan-loading had an opposite, voltage-increasing effect, on the 30 schizophrenic subjects tested. This abnormal response was greatest in the male and postmenopausal schizophrenic subjects. Besides this sex effect, the abnormality increased with age up to a point, and was decreased by antipsychotic medication and cortisol. An explanation in terms of an abnormality in the relative hydroxylation of indoles in schizophrenic subjects is proposed.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 039244069

Download citation: RISBibTeXText

PMID: 986840


Related references

Responses of prolactin and growth hormone to L-tryptophan infusion: effects in normal subjects and schizophrenic patients receiving neuroleptics. Psychopharmacology 86(1-2): 164-169, 1985

Electrophysiological studies on the brain. Effects of nucleotide and tryptophan metabolites as modified by polyamines in normal and psychotic subjects. Diseases of the Nervous System 31(11): 772-780, 1970

Electrophysiological phenomena associated with the S-protein system in normal and schizophrenic subjects. Biological Psychiatry 7(2): 113-127, 1973

Erythrocyte acid phosphatase distributions in normal, schizophrenic and mentally retarded subjects. Clinical Genetics 3(5): 341-346, 1972

A comparison of the performance of matched groups of schizophrenic patients, normal subjects, and delinquent subjects on some aspects of the Stanford Binet. Journal of Educational Psychology 28(7): 519-529, 1937

Tryptophan loading and excretion of 5-hydroxyindoleacetic acid in normal and schizophrenic subjects. Science 129(3352): 835-836, 1959

A comparative study of the aging process in groups of schizophrenic and mentally well veterans. Geriatrics 13(6): 367-370, 1958

Cortisol secretion and cortisol degradation products in the urine of obese subjects in comparison to normal subjects. Klinische Wochenschrift 39: 702-703, 1961

Relationship between serum tryptophan and tryptophan metabolite levels after tryptophan ingestion in normal subjects and age-related cataract patients. Clinical Science 89(6): 591-599, 1995

Preparation of an immunoadsorbent interacting specifically with cortisol-binding globulin (CBG) and its application to the interaction between CBG and cortisol--evaluation of the association constant (Ka) between CBG and cortisol in normal subjects. Nihon Naibunpi Gakkai Zasshi 63(5): 695-701, 1987

Preparation of immunoadsorbent which interacts specifically with cortisol binding globulin cbg and its application for the interaction between cbg and cortisol evaluation of association constant ka between cbg and cortisol in normal subjects. Folia Endocrinologica Japonica 63(5): 695-701, 1987

Brain tryptophan metabolism in schizophrenia a post mortem study of metabolites on the serotonin and kynurenine pathways in schizophrenic and control subjects. Psychopharmacology 62(3): 279-286, 1979

Effects of trazodone on plasma cortisol in normal subjects. A study with drug plasma levels. Neuropsychopharmacology 5(1): 61-64, 1991

Intra venous l 5 hydroxy tryptophan in normal subjects an interdisciplinary precursor loading study part 4 effects on body temperature and cardio vascular functions. Pharmakopsychiatrie Neuro Psychopharmakologie: 289-294, 1976

A comparative study of regression in Iranian schizophrenic and normal groups. Acta Medica Iranica 19(3): 219-225, 1976