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An endogenous membrane-bound protein inhibits the phosphorylation of the L-type calcium channel by the cAMP-dependent protein kinase



An endogenous membrane-bound protein inhibits the phosphorylation of the L-type calcium channel by the cAMP-dependent protein kinase



Biochemical and Biophysical Research Communications 186(3): 1588-1593



An endogenous protein inhibits the PKA-phosphorylation of the DHP-binding calcium channel complex in vitro. The inhibitory activity could be reduced by a treatment with detergents or dithiothreitol. Further purification separates the inhibitory activity from the dihydropyridine-binding calcium channel complex. Both activities are localized in the plasma membrane indicating that this protein kinase-inhibitor could interfere with the phosphorylation of the calcium channel by the cAMP-dependent protein kinase. The inhibitory activity may therefore take part in the regulation of the calcium channel current.

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Accession: 039244402

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PMID: 1324670

DOI: 10.1016/s0006-291x(05)81589-x


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