An immunoelectrophoretic study of plasma lipoproteins in a case of familial deficiency of lecithin-cholesterol acyltransferase

Salmon, S.; Alcindor, L.G.; Beucler, I.; Ayraul-Jarrier, M.; Infante, R.; Chevet, D.; Polonovski, J.

Clinica Chimica Acta; International Journal of Clinical Chemistry 66(3): 311-318


ISSN/ISBN: 0009-8981
PMID: 174839
DOI: 10.1016/0009-8981(76)90230-8
Accession: 039249662

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The lipid composition and apopeptide patterns of plasma LDL and VLDL have been studied in a patient with LCAT deficiency, using two-dimensional immunoelectrophoresis. After absorption of a fat meal an elevation of VLDL apopeptides C was observed. Apo-LDL also showed an abnormal relative increase of apo-C. After heparin-induced lipolysis, a shift of apo-C from chylomicra and VLDL to LDL was noticed by the striking increase of apo-C in this last lipoprotein class. In view of the present and previously published results the possible mechanisms involved in lipoprotein catabolism in LCAT deficiency are discussed.