An immunoelectrophoretic study of plasma lipoproteins in a case of familial deficiency of lecithin-cholesterol acyltransferase

Salmon, S.; Alcindor, L.G.; Beucler, I.; Ayraul-Jarrier, M.; Infante, R.; Chevet, D.; Polonovski, J.

Clinica Chimica Acta; International Journal of Clinical Chemistry 66(3): 311-318

1976


ISSN/ISBN: 0009-8981
PMID: 174839
DOI: 10.1016/0009-8981(76)90230-8
Accession: 039249662

Download citation:  
Text
  |  
BibTeX
  |  
RIS

Article/Abstract emailed within 0-6 h
Payments are secure & encrypted
Powered by Stripe
Powered by PayPal

Abstract
The lipid composition and apopeptide patterns of plasma LDL and VLDL have been studied in a patient with LCAT deficiency, using two-dimensional immunoelectrophoresis. After absorption of a fat meal an elevation of VLDL apopeptides C was observed. Apo-LDL also showed an abnormal relative increase of apo-C. After heparin-induced lipolysis, a shift of apo-C from chylomicra and VLDL to LDL was noticed by the striking increase of apo-C in this last lipoprotein class. In view of the present and previously published results the possible mechanisms involved in lipoprotein catabolism in LCAT deficiency are discussed.