+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Anti-endothelial cell antibodies and circulating immune complexes in the sera of patients with multiple sclerosis



Anti-endothelial cell antibodies and circulating immune complexes in the sera of patients with multiple sclerosis



Journal of Neuroimmunology 17(1): 49-59



Sera from patients with multiple sclerosis (MS) were examined for anti-endothelial cell antibodies and immune complexes by enzyme-linked immunosorbent assays (ELISAs) using cultured brain endothelial cells and Raji cells respectively. The concentrations of immunoglobulin (Ig) G which bound to cerebral endothelial cells and of immune complexes were significantly increased in the sera of patients with MS, especially those with an exacerbation. The levels of IgG binding to endothelial cells were still increased in the sera of exacerbated MS patients after blocking Fc receptors compared to those of controls. These findings indicate that IgG binding to endothelial cells may be mediated via an immunologically specific antigen-antibody interaction. The results show that anti-endothelial cell antibodies and immune complexes are present in cases of MS and they may play a pathogenetic role in the blood-brain barrier (BBB) damage.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 039289749

Download citation: RISBibTeXText

PMID: 2445776

DOI: 10.1016/0165-5728(87)90030-0


Related references

Anti-lymphocyte antibodies and circulating immune complexes in the sera of patients with myelopathy associated with human T lymphotropic virus type-I. Journal of Neuroimmunology 42(2): 161-166, 1993

Absence of brain antibodies in the sera of relapsing-remitting multiple sclerosis patients is not due to the formation of immune complexes. Acta Neurologica Scandinavica. 87(6): 455-456, 1993

Anti-endothelial cell antibody activities in sera of patients with multiple sclerosis. Journal of Neurochemistry 64(Suppl. 1): S92, 1995

Correlation and characterization of islet cell antibodies circulating immune complexes and anti nuclear antibodies in diabetic patients. Immunobiology 156(3): 246-247, 1979

Circulating immune complexes and viral antibodies in multiple sclerosis. Journal of Neuroimmunology (Suppl. 1): S31, 1982

Different mode of circulating immune complexes and anti-ssDNA antibodies in sera of lepromatous leprosy and systemic lupus erythematosus. Leprosy Review 55(3): 291-299, 1984

Circulating immune complexes in human tuberculosis sera: Demonstration of specific antibodies against Mycobacterium tuberculosis glycolipid (DAT, PGLTb1, LOS) antigens in isolated circulating immune complexes. European Journal of Clinical Investigation 27(2): 128-134, 1997

Different mode of circulating immune complexes and anti single stranded dna antibodies in sera of lepromatous leprosy and systemic lupus erythematosus. Leprosy Review 55(3): 291-300, 1984

Sedimentation of circulating immune complexes with polyethylene glycol combined with immunoenzyme method--a new approach to analysis of circulating immune complexes in the sera of patients with rheumatic diseases. Revmatologiia .(2): 26-28, 1991

Anti-glycolipid antibodies and their immune complexes in multiple sclerosis. Journal of the Neurological Sciences 75(1): 33-42, 1986

Antinuclear antibodies and circulating immune complexes in sera of patients with recurrent pregnancy loss. American Journal of Reproductive Immunology 28(3-4): 292, 1992

Circulating antibodies directed against conjugated fatty acids in sera of patients with multiple sclerosis. Journal Of Neuroimmunology. 65(1): 75-81, 1996

Circulating immune complexes in leprosy sera: demonstration of antibodies against mycobacterial glycolipidic antigens in isolated immune complexes. International Journal of Leprosy and other Mycobacterial Diseases 61(1): 44-50, 1993

Immune complexes in the sera of patients with anti-RNP antibodies. Journal of Dermatology 8(1): 21-26, 1981

Antibodies against myelin basic protein and myelin associated glycoprotein in the central spinal fluid of multiple sclerosis patients the influence of prednisone medication on autoantibodies and circulating immune complexes level. Folia Medica Cracoviensia 25(3-4): 307-318, 1984