+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Anticonvulsant properties of 3-hydroxy-2-quinoxalinecarboxylic acid, a newly found antagonist of excitatory amino acids



Anticonvulsant properties of 3-hydroxy-2-quinoxalinecarboxylic acid, a newly found antagonist of excitatory amino acids



European Journal of Pharmacology 110(1): 31-39



Various aromatic acids have been investigated as putative ligands of excitatory amino acid receptors. 3-Hydroxy-2-quinoxalinecarboxylic acid (HQC), at 1 mM, was found to antagonize the 22Na+ efflux produced in 22Na+-preloaded brain slices by N-methyl-D-aspartate and kainate. The response to glutamate was also affected but not that to quisqualate. The apparent KI value of HQC for suppression of the N-methyl-D-aspartate response was 0.27 mM. The anticonvulsant action of HQC was investigated in mice and rats. HQC administered intracerebroventricularly caused a dose dependent delay in the occurrence of picrotoxin induced convulsions and afforded protection against picrotoxin induced death. These results confirm the proposition that antagonists of excitatory amino acids possess anticonvulsant properties.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 039297555

Download citation: RISBibTeXText

PMID: 2861099

DOI: 10.1016/0014-2999(85)90025-1


Related references

2 amino 6 trifluoromethoxybenzothiazole a possible antagonist of excitatory amino acid neurotransmission 1. anticonvulsant properties. Neuropharmacology 24(8): 767-774, 1985

A dipeptide derived from kainic and L-glutamic acids: a selective antagonist of amino acid induced neuroexcitation with anticonvulsant properties. Journal of Medicinal Chemistry 28(12): 1957-1958, 1985

6,7-Dichloro-3-hydroxy-2-quinoxalinecarboxylic acid is a relatively potent antagonist at NMDA and kainate receptors. Neuroscience Letters 91(2): 194-198, 1988

Synaptosomal release of newly-synthetized or recently accumulated amino acids. Differential effects of kainic acid on naturally occurring excitatory amino acids and on [d-(3)H]aspartate. Neurochemistry International 9(1): 29-33, 1986

Synaptosomal release of newly synthetized or recently accumulated amino acids differential effects of kainic acid on naturally occurring excitatory amino acids and on tritiated d aspartate. Neurochemistry International 9(1): 29-34, 1986

Is 1-hydroxy-3-aminopyrrolidone-2 (HA-966) a selective excitatory amino-acid antagonist?. Nature: New Biology 238(80): 61-63, 1972

The effects of intrathecal administration of several inhibitory amino acids and an excitatory amino acid antagonist in the spastic mutant mouse. Society for Neuroscience Abstracts 12(2): 1251, 1986

2-Amino-6-trifluoromethoxy benzothiazole, a possible antagonist of excitatory amino acid neurotransmission--II. Biochemical properties. Neuropharmacology 24(11): 1085-1092, 1985

Antagonist profile of 6,7-dichloro-3-hydroxy-2-quinoxalinecarboxylate at excitatory amino acid receptors in the neonatal rat spinal cord. European Journal of Pharmacology 163(1): 127-131, 1989

Alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate excitatory amino acid receptor antagonistic properties of YM900 -7-nitroquinoxaline-2,3 -dione. Society for Neuroscience Abstracts 18(1-2): 87, 1992

A study of the molecular structure and spectroscopic properties of 3-hydroxy-2-quinoxalinecarboxylic acid by experimental methods and quantum chemical calculations. Spectrochimica Acta. Part A Molecular and Biomolecular Spectroscopy 101: 14-21, 2013

Glutamate: three meetings but how many receptors? Excitatory Amino Acids 1990: a Fidia Research Foundation Symposium, Padua, Italy, May 21-26, 1990. Excitatory Amino Acid Receptors in the Brain: Functions and Disorders, Montreal, Canada, June 23-24, 1990. Excitatory Amino Acids: an Update Official Satellite of the XIth IUPHAR Congress, Flims, Switzerland, June 28-29, 1990. New Biologist 2(10): 865-869, 1990

Effect of antagonists of excitatory amino acids on neurodegenerative action of quinolinic acid in vitro compared with their anticonvulsant action in situ. Bulletin of Experimental Biology and Medicine 108(2): 1129-1132, 1989

Retardation of amygdaloid kindling by and the behavioral effects of kynurenic acid an antagonist of excitatory amino acids a preliminary report. Society for Neuroscience Abstracts 13(2): 761, 1987

Neurology and neurobiology vol. 46. frontiers in excitatory amino acid research international symposium excitatory amino acids '88 manaus amazonas brazil march 28 april 2 1988. Cavalheiro, E A , J Lehmann And L Turski (Ed ) Neurology And Neurobiology, Vol 46 Frontiers in Excitatory Amino Acid Research; International Symposium Excitatory Amino Acids '88, Manaus, Amazonas, Brazil, March 28-April 2, Xxxvi+745p Alan R Liss, Inc : New York, New York, Usa Illus Xxxvi+745p, 1988