+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Are event-related potentials in multiple sclerosis indicative of cognitive impairment? Evoked and event-related potentials, psychometric testing and response speed: a controlled study



Are event-related potentials in multiple sclerosis indicative of cognitive impairment? Evoked and event-related potentials, psychometric testing and response speed: a controlled study



Journal of the Neurological Sciences 109(1): 18-24



Bimodal event-related potentials (ERPs), together with evoked potentials (EPs), measures of motor speed (tapping test, EMG latencies and reaction times (RT)), and psychometric test results were studied in a group of 30 multiple sclerosis (MS) patients and 19 controls. ERPs have been advocated as objective tests of cognitive function. In the present study ERPs were compared with the results of psychometric tests, which have a proven validity in measuring aspects of cognitive function that are important in daily life. Abnormal EMG, RT and tapping speed confirmed that motor aspects of performance were slowed in the MS group. In contrast, cognitive non-motor variables such as Raven-IQ and MQ were not significantly abnormal. The proportions of abnormal ERP N2 and P3 latencies did not differ between the groups. It is concluded that the slow performance of MS subjects is therefore most likely not due to cognitive speed decrement, but to motor, executive impairments. No significant relationships between ERP latencies and psychometric test results were found. This held even for a subgroup of 5 MS patients with psychometrically established cognitive impairments. Based on these results, we query the relevance of ERPs as subtle indicators of cognitive impairment in MS.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 039317798

Download citation: RISBibTeXText

PMID: 1517761

DOI: 10.1016/0022-510x(92)90088-3


Related references

What is the validity of an "abnormal" evoked or event-related potential in MS? Auditory and visual evoked and event-related potentials in multiple sclerosis patients and normal subjects. Journal of the Neurological Sciences 109(1): 11-17, 1992

Different sensitivity of pain-related chemosensory potentials evoked by stimulation with CO-2, tooth pulp event-related potentials, and acoustic event-related potentials to the tranquilizer diazepam. British Journal of Clinical Pharmacology 38(6): 545-555, 1994

Cognitive impairment and event-related potentials in paediatric multiple sclerosis: 2-year study. Neurological Sciences 32(6): 1043-1046, 2011

Neuropsychological testing and event-related potentials in the assessment of cognitive performance in the patients with multiple sclerosis--a pilot study. Clinical Neurology and Neurosurgery 111(6): 503-506, 2009

The relationship between event-related potentials, stress perception and personality type in patients with multiple sclerosis without cognitive impairment: A pilot study. Advances in Clinical and Experimental Medicine 27(6): 787-794, 2018

Early diagnosis of mild cognitive impairment and Alzheimer's with event-related potentials and event-related desynchronization in N-back working memory tasks. Computer Methods and Programs in Biomedicine 164: 1-13, 2018

Event-related auditory evoked potentials and multiple sclerosis. Electroencephalography and Clinical Neurophysiology 88(3): 182-187, 1993

Event related auditory evoked potentials and multiple sclerosis. Journal of Neurology 237(Suppl. 1): S39, 1990

Cognitive event-related potentials in multiple sclerosis. Brain 112: 1637-1660, 1989

Event-related potentials in the assessment of cognitive function in multiple sclerosis. Electroencephalography and Clinical Neurophysiology. Supplement 50: 469-479, 1999

Structural MRI Correlates of Cognitive Event-Related Potentials in Multiple Sclerosis. Journal of Clinical Neurophysiology 35(5): 399-407, 2018

Cognitive impairment in amyotrophic lateral sclerosis: evidence from neuropsychological investigation and event-related potentials. Brain Research. Cognitive Brain Research 14(2): 234-244, 2002

Changes in topography in cognitive event related potentials in demented multiple sclerosis patients. Neurology 40(4 Suppl. 1): 151, 1990

Cognitive event-related potentials in multiple sclerosis: Correlation with MRI and neuropsychological findings. Multiple Sclerosis and Related Disorders 10: 192-197, 2016

Event-related potentials and cognitive performance in multiple sclerosis patients with fatigue. Neurological Sciences 37(9): 1545-1556, 2016