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Atrial natriuretic factor (ANF) levels are elevated in rats bearing rejecting heart-lung allografts



Atrial natriuretic factor (ANF) levels are elevated in rats bearing rejecting heart-lung allografts



Biochemical and Biophysical Research Communications 146(2): 625-629



Intra-abdominal heart-lung grafts were transplanted into 8 rats across a major histocompatibility barrier. Four of the 8 rats were treated with Cyclosporin A (CsA) to prevent rejection. Atrial natriuretic factor (ANF) levels measured 6 days after transplantation revealed a significantly (p less than .005) higher mean ANF concentration in rats bearing a rejecting heart-lung allograft (642 +/- 148.0 pg/ml) compared to rats bearing a heart-lung allograft not undergoing rejection (200.8 +/- 13.07 pg/ml). ANF might be a useful noninvasive marker in the diagnosis of rejection in heart and heart-lung transplants.

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Accession: 039343302

Download citation: RISBibTeXText

PMID: 2956947

DOI: 10.1016/0006-291x(87)90574-2


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