+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Atrial natriuretic factor (ANF) stimulates the release of alpha-MSH from frog neurointermediate lobes in vitro. Interaction with dopamine, GABA and neuropeptide Y



Atrial natriuretic factor (ANF) stimulates the release of alpha-MSH from frog neurointermediate lobes in vitro. Interaction with dopamine, GABA and neuropeptide Y



Life Sciences 40(19): 1853-1857



The action of atrial natriuretic factor (ANF) on alpha-MSH release from frog neurointermediate lobe was studied in vitro using a perifusion technique. Synthetic ANF Arg101-Tyr 126, at concentrations ranging from 10(-7) to 10(-5)M, caused a dose-related stimulation of alpha-MSH release. In addition, dopamine, GABA and NPY, three neuroendocrine factors which inhibit alpha-MSH secretion totally suppressed the action of ANF on alpha-MSH production. The neural lobe of the amphibian pituitary contains numerous ANF immunoreactive fibers, and this regulatory peptide may diffuse from nerves terminating in the pars nervosa to the pars intermedia. Thus, our results suggest that ANF of hypothalamo-neurohypophysial origin may be involved in the multineuronal regulation of amphibian melanotrophs.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 039343303

Download citation: RISBibTeXText

PMID: 2952856


Related references

The melanotropic peptides ii. atrial natriuretic factor anf stimulates the release of alpha msh from frog neurointermediate lobes in vitro interaction with dopamine gaba and neuropeptide y. Life Sciences 40(19): 1853-1858, 1987

Atrial natriuretic factor ANF stimulates the release of -MSH from frog neurointermediate lobes in vitro Interaction with dopamine, GABA and neuropeptide Y. Life Sciences 4019: 1853-1857, 1987

Thyrotropin-releasing hormone stimulates the release of melanotropin from frog neurointermediate lobes in vitro. Life Sciences 26(11): 869-876, 1980

GABA-ergic control of alpha-melanocyte-stimulating hormone (alpha-MSH) release by frog neurointermediate lobe in vitro. Brain Research Bulletin 17(5): 717-723, 1986

Interaction of corticotropin-releasing factor (CRF) and alpha-helical CRF on rat neurointermediate lobes: in vitro studies. Neuropeptides 19(3): 213-221, 1991

Why are several inhibitory transmitters present in the innervation of pituitary melanotrophs? Actions and interactions of dopamine, GABA and neuropeptide Y on secretion from neurointermediate lobes of Xenopus laevis. Neuroendocrinology 54(6): 599-606, 1991

Interactions of corticotropin releasing factor crf and alpha helical crf on peptide release from rat neurointermediate lobes in vitro. Society for Neuroscience Abstracts 15(2): 1079, 1989

Central type benzodiazepines and the octadecaneuropeptide modulate the effects of gaba on the release of alpha msh from frog neurointermediate lobe in vitro. Neuroscience 31(2): 485-494, 1989

Central-type benzodiazepines and the octadecaneuropeptide modulate the effects of GABA on the release of alpha-melanocyte-stimulating hormone from frog neurointermediate lobe in vitro. Neuroscience 31(2): 485-493, 1989

Comparative effects of corticotropin releasing factor arginine vasopressin and related neuropeptides on the secretion of acth and alpha msh by frog anterior pituitary cells and neurointermediate lobes in vitro. General & Comparative Endocrinology 61(3): 438-445, 1986

Benzodiazepines and the octadecaneuropeptide odn modulate the effects of gaba on alpha msh release from frog neurointermediate lobe. General & Comparative Endocrinology 74(2): 301, 1989

Catecholaminergic control of alpha-melanocyte-stimulating hormone (alpha MSH) release by frog neurointermediate lobe in vitro: evidence for direct stimulation of alpha MSH release by thyrotropin-releasing hormone. Endocrinology 112(1): 133-141, 1983

The benzodiazepine agonist clonazepam potentiates the effects of gamma-aminobutyric acid on alpha-MSH release from neurointermediate lobes in vitro. Life Sciences 40(19): 1881-1887, 1987

Atrial natriuretic factor stimulates renal dopamine uptake mediated by natriuretic peptide-type A receptor. Regulatory Peptides 124(1-3): 137-144, 2005

The melanotropic peptides vi. the benzodiazepine agonist clonazepam potentiates the effects of gamma aminobutyric acid on alpha msh release from neurointermediate lobes in vitro. Life Sciences 40(19): 1881-1888, 1987