+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Attenuation of isobutylmethylxanthine-induced suppression of operant behavior by pretreatment of rats with clonidine

Attenuation of isobutylmethylxanthine-induced suppression of operant behavior by pretreatment of rats with clonidine

Pharmacology, Biochemistry, and Behavior 28(2): 235-241

Administration of 3-isobutyl-1-methylxanthine (IBMX) to rats performing a FR30 operant for food reinforcement produces a dose-dependent suppression of behavior. Operant behavior suppressed by 5 mg IBMX/kg is attenuated by pretreatment, 30 min before the operant session, with the alpha 2 adrenergic agonist clonidine (5-30 micrograms/kg). Clonidine itself causes a dose-dependent reduction in FR30 responding prior to the administration of IBMX. However, doses of clonidine which also suppressed responding were not more effective than lower doses in attenuating the suppression of operant behavior caused by IBMX, perhaps due to postsynaptic or nonspecific actions of clonidine. Methylxanthines, alone or in combination with the opiate antagonist naloxone, produce signs of opiate withdrawal. This quasi-morphine withdrawal syndrome may be useful in studies of either the development or expression of opiate withdrawal. Since clonidine attenuates the rate-suppressant effect of IBMX, it is likely that a significant component of IBMX's behavioral effects are due to increases in NE neurotransmission. These results are similar to those obtained with true opiate withdrawal in rats, strengthening the idea that suppression of operant behavior by IBMX involves mechanisms in common with opiate withdrawal. It may be a useful way of objectively studying the expression of the withdrawal syndrome in the absence of opiates and/or a way of determining if a drug can selectively block withdrawal.

Please choose payment method:

(PDF emailed within 0-6 h: $19.90)

Accession: 039346049

Download citation: RISBibTeXText

PMID: 2446338

DOI: 10.1016/0091-3057(87)90220-6

Related references

Suppression of operant behavior and schedule-induced licking in rats. Journal of the Experimental Analysis of Behavior 20(3): 375-383, 1973

d-Amphetamine antagonizes prostaglandin E1-induced hyperthermia and suppression of fixed interval operant behavior in rats. Pharmacology, Biochemistry, and Behavior 21(4): 575-581, 1984

Dextro amphetamine antagonizes prostaglandin e 1 induced hyperthermia and suppression of fixed interval operant behavior in rats. Pharmacology Biochemistry & Behavior 21(4): 575-582, 1984

Lesion of serotonergic neurons antagonizes clonidine induced suppression of avoidance behavior and locomotor activity in rats. Psychopharmacology 73(3): 261-264, 1981

Clonidine antagonizes naloxone-induced suppression of conditioned behavior and body weight loss in morphine-dependent rats. Pharmacology, Biochemistry, and Behavior 9(3): 319-325, 1978

Attenuation of conflict induced suppression by clonidine indication of anxiolytic activity. Drug Development Research 1(2): 137-144, 1981

Clonidine antagonizes disruption of fixed ratio operant behavior in morphine pelleted rats given naloxone. Pharmacologist: 236, 1976

Environmental influences upon drug induced suppression of operant behavior. Journal of Pharmacology and Experimental Therapeutics 179(1): 1-9, 1971

Operant behavior and drinking suppression in vasopressin-deficient rats (Brattleboro strain). Behavioural Brain Research 15(1): 71-74, 1985

Clonidine suppresses copulatory behavior and erectile reflexes in male rats: lack of effect of naloxone pretreatment. Neuroendocrinology 51(3): 357-364, 1990

Environmental influences upon morphine or d-amphetamine induced suppression of operant behavior. Pharmacology, Biochemistry, and Behavior 1(1): 133-136, 1973

Clonidine pretreatment inhibits stress-induced gastric ulcer in rats. Anesthesia and Analgesia 89(1): 159-162, 1999

Suppression of copulatory behavior in male rats following central administration of clonidine. Neuropharmacology 30(4): 373-382, 1991

The effects of naloxone, chlorpromazine, and haloperidol pretreatment on levallorphan-induced disruption of rats' operant behaviour. Psychopharmacologia 22(3): 261-270, 1971

Activation of alpha 2-adrenoreceptors enhances haloperidol-induced suppression of operant behavior. Journal of Neural Transmission 66(2): 107-120, 1986