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Beta-endorphin-(1-27) antagonizes beta-endorphin-induced hypothermia in mice

Beta-endorphin-(1-27) antagonizes beta-endorphin-induced hypothermia in mice

Peptides 8(1): 123-126

The effects of beta-endorphin and beta-endorphin-(1-27) on the body temperature of mice was studied at an ambient temperature of 10 degrees C. Intracerebroventricular injection of beta-endorphin (0.25-4 micrograms) and beta-endorphin-(1-27) (0.61 to 10 micrograms) caused a dose-related hypothermia. The duration of hypothermia induced by beta-endorphin-(1-27) was shorter than that induced by beta-endorphin. The hypothermia induced by 2 micrograms of beta-endorphin was attenuated by 5 micrograms of beta-endorphin-(1-27). Our results indicated that beta-endorphin-(1-27) is a partial agonist which produces a small degree of hypothermia and an antagonist which blocks the beta-endorphin-induced hypothermia.

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Accession: 039381486

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PMID: 2952945

DOI: 10.1016/0196-9781(87)90175-6

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