Binding of C14-histamine by plasma membranes of cells from gastric mucosa of rats

Bersimbaev, R.I.

Voprosy Meditsinskoi Khimii 22(6): 728-732

1976


ISSN/ISBN: 0042-8809
PMID: 1027247
Accession: 039388310

Download citation:  
Text
  |  
BibTeX
  |  
RIS

Article/Abstract emailed within 1 workday
Payments are secure & encrypted
Powered by Stripe
Powered by PayPal

Abstract
It was established that in rat gastric mucosa cells the receptor proteins capable of binding 14C-histamine were components of plasma membranes. Analysis (by Scatchard method) of curves of 14C-histamine binding by receptor proteins demonstrated that in plasma membranes there were two types of receptors: with high and low affinity to histamine. A specific histamine H2-receptor blockator--burimamide--inhibited competitively the binding of labelled histamine by plasma membranes. The data obtained suggest that the activation of adenyl cyclase by histamine is the result of specific binding of this amine by proteins of plasma membranes in rat gastric mucosa cells.