+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Biological hepatic abnormalities, cholestatic jaundice and hospital artificial nutrition. A comparative study in adults with cyclic total parenteral nutrition and enteral nutrition



Biological hepatic abnormalities, cholestatic jaundice and hospital artificial nutrition. A comparative study in adults with cyclic total parenteral nutrition and enteral nutrition



Gastroenterologie Clinique et Biologique 12(4): 326-331



Two hundred and fourteen hospitalized nonsurgical, nonacutely stressed adult patients, who were receiving, either prolonged (greater than 21 days) cyclic total parenteral nutrition (n = 106) or enteral nutrition (n = 108), including lipids, for gastrointestinal disorders, and who were free of prenutrition liver function test abnormalities were prospectively investigated for hepatic dysfunction: 41 p. 100 and 17 p. 100 of parenteral and enteral nutrition patients, respectively, developed abnormalities of liver function tests after 25 +/- 5 and 21 +/- 4 days (p less than 0.01). This prevalence was unrelated to catheter sepsis, blood transfusion, caloric load, site of digestive disease or initial nutritional status, and decreased by 50 and 40 p. 100 before the end of total parenteral nutrition and enteral nutrition respectively. In the parenteral nutrition group, separate infusion of lipids, as compared with mixed infusion, was associated with a lower rate of hepatic dysfunction (29 vs 54 p. 100; p less than 0.02). Nine (8.5 p. 100) parenteral nutrition but no enteral nutrition patients developed severe cholestatic jaundice, 47 +/- 39 days after the onset of liver function test abnormalities; no identifiable cause excepting parenteral nutrition per se was found in 3 patients with diffuse obstructive small intestinal disease; jaundice led to death from noncirrhotic hepatic failure in the 2 patients who remained totally parenteral nutrition-dependent.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 039398206

Download citation: RISBibTeXText

PMID: 3133275


Related references

Comparative prevalence and evolution of hepatic biological anomalies during cyclic parenteral nutrition and continuous enteral nutrition of the adult in the hospital. Gastroenterologie Clinique et Biologique 10(3): 269, 1986

Liver function tests abnormalities in patients with inflammatory bowel disease receiving artificial nutrition: a prospective randomized study of total enteral nutrition vs total parenteral nutrition. Jpen. Journal of Parenteral and Enteral Nutrition 14(6): 618-621, 1990

Liver function tests abnormalities in patients with inflammatory bowel disease receiving artificial nutrition a prospective randomized study of total enteral nutrition versus total parenteral nutrition. Journal of Parenteral & Enteral Nutrition 14(6): 618-621, 1990

Role of artificial nutrition (total parenteral nutrition/total enteral nutrition) support in the treatment of inflammatory bowel diseases. Zhonghua Wai Ke Za Zhi 23(4): 193-5 252, 1985

Prevalence of cholestatic jaundice during hospital cyclic total parenteral nutrition a prospective study in gastrointestinal adult patients. Journal of Hepatology 3(1): 11P, 1986

Combined enteral-parenteral nutrition versus total parenteral nutrition in brain-injured patients. A comparative study. Intensive Care Medicine 11(2): 80-84, 1985

Total enteral nutrition versus total parenteral nutrition after major torso injury: attenuation of hepatic protein reprioritization. Surgery 104(2): 199-207, 1988

Enteral nutrition and total parenteral nutrition components in the course of total parenteral nutrition-associated cholestasis in neonatal necrotizing enterocolitis. Surgery 156(3): 578-583, 2014

Enteral nutrition rapidly reverses total parenteral nutrition-induced impairment of hepatic immunity in a murine model. Clinical Nutrition 28(6): 668-673, 2009

Nutrition Management of the Very Low-birthweight Infant: I. Total Parenteral Nutrition and Minimal Enteral Nutrition. Neoreviews 7(12): E602-E607, 2006

The outcome of nutrition support of surgery patients with hypermetabolic severity by total parenteral nutrition and enteral nutrition and biochemical data. Korean Journal of Community Nutrition 11(2): 289-297, 2006

Prevalence and evolution of cholestatic jaundice associated with cyclic total parenteral nutrition in the adult prospective study in 105 patients treated for over 21 days. Gastroenterologie Clinique et Biologique 10(3): 261, 1986

Effects of cyclic (nocturnal) total parenteral nutrition and continuous enteral nutrition on circadian rhythms of blood lipids, lipoproteins and apolipoproteins in humans. American Journal of Clinical Nutrition 41(4): 727-734, 1985

Cholestatic jaundice during total parenteral nutrition. Canadian Journal of Surgery. Journal Canadien de Chirurgie 21(4): 332-339, 1978

G429(P)Smof parenteral nutrition is an effective option in the long term nutrition of preterm infants and associated with less cholestatic jaundice. Archives of Disease in Childhood 101(Suppl 1): A253.2-A253, 2016