Biological studies on 1,2-benzisothiazole derivatives. II. Evaluation of antibacterial, antifungal and DNA-damaging activities of 3-amino, 3-acylamino, 3-alkylaminoacylamino derivatives

Zani, F.; Massimo, G.; Coghi, E.; Bellotti, A.; Mazza, P.

Farmaco 44(10): 997-1006

1989


ISSN/ISBN: 0014-827X
PMID: 2515866
Accession: 039398999

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Abstract
The in vitro evaluation of antibacterial, antifungal and DNA-damaging properties of some 3-amino, 3-acylamino and 3-alkylaminoacylamino derivatives of 1,2-benzisothiazole is described. Compounds 1-8, 38 and 48 exhibited a selective antifungal activity while the other compounds did not show any significative activity. None of the compounds tested turned out to have any genotoxic properties.