Section 40
Chapter 39,408

Blocking effect of J chain and J-chain antibody on the binding of secretory component to human IgA and IgM

Brandtzaeg, P.

Scandinavian Journal of Immunology 4(8): 837-842


ISSN/ISBN: 0300-9475
PMID: 814614
DOI: 10.1111/j.1365-3083.1975.tb03725.x
Accession: 039407507

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Isolated released J chain showed only a small affinity for free secretory component (SC), as indicated by a marginal but reproducible blocking effect on the binding of SC to Ig polymers. The SC-binding site was completely blocked by J-chain antibody in those Ig polymers where the bound J chains were accessible to the antibody. Along with the established masking effect of SC on the antigenicity of J chains present in secretory IgA, these results are compatible with the idea that the conformation of Ig-associated J chains contributes to the SC-binding site of Ig polymers.

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