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Bronchial responsiveness to inhaled leukotriene D4 in bronchial asthma. Part. 1. Comparison of the bronchial responsiveness of asthmatic patients to leukotriene D4, acetylcholine and histamine



Bronchial responsiveness to inhaled leukotriene D4 in bronchial asthma. Part. 1. Comparison of the bronchial responsiveness of asthmatic patients to leukotriene D4, acetylcholine and histamine



Arerugi 36(9): 838-847



In order to determine the role of leukotriene (LT) in bronchoconstriction in asthmatic patients, we compared the bronchial responsiveness to LTD4 of seven normal subjects and twenty six asthmatic subjects, and this was compared with the responsiveness to acetylcholine and histamine in the same asthmatic subjects. We carried out the LTD4 inhalation test using siliconized glass nebulizers, with the inhalation of 1 ml solution of an increasing concentration. Acetylcholiae and histamine inhalation test were carried out according to the standard method. Bronchial responsiveness was expressed as the cumulative dose or number of units causing a 20% fall in FEV1.0 (PD20), where one unit is defined as the inhalation of 1 .mu.g/ml solution of acetylcholine or histamine for 1 minute. The inhalation of 20000 ng of LTD4 did not decrease FEV1.0 by more than 20% in any of the normal subjects, but decreased it by 11.3 .+-. 5.1% (mean .+-. SD). In the asthmatic subjects PD20-LTD4 ranged from 30 ng to 14990 ng with a mean of 562 ng. The bronchi of the asthmatic subjects were over 40 times more sensitive to LTD4 than those of the normal subjects. There is statistically significant correlation between PD20-LTD4 and PD20-Ach (r=0.690, p < 0.001), PD20-LTD4 and PD20-Hist (r=0.628, p < 0.001). In addition LTD4 has an approximately 200 times more potent bronchoconstrictive effect in asthmatic patients than histamine and 700 times more than acetylcholine. Furthermore, patients with more severe asthmatic symptoms tend to have lower PD2O-LTD4 than patients with milder symptoms. These results suggest that LTD4 has an important role in the bronchoconstriction of asthmatic patients.

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Accession: 039427253

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PMID: 3435245


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