Burn-induced gastric mucosal hemodynamic disturbance in the rat. Role of platelet-activating factor

Binnaka, T.; Yamaguchi, T.; Kubota, Y.; Fujimura, K.; Tani, K.; Kitagawa, S.; Mizuno, T.; Inoue, K.

Scandinavian Journal of Gastroenterology 27(2): 89-92


ISSN/ISBN: 0036-5521
PMID: 1561532
DOI: 10.3109/00365529209165423
Accession: 039430943

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The role of platelet-activating factor (PAF) as a mediator of gastric damage associated with burn injury was examined in the rat. Gastric mucosal hemodynamics was recorded continuously by means of laser-Doppler flowmetry and reflectance spectrophotometry. Burn injury induced prolonged hypotension and rapid-onset and long-lasting gastric mucosal hemodynamic derangement-that is, ischemia with congestion. This hemodynamic disturbance was significantly inhibited by CV-6209, a specific PAF antagonist. Elevated tissue levels of thiobarbituric acid reactants and pathologic changes in the gastric mucosa subsequent to burn injury were also significantly alleviated by the preadministration of CV-6209. These results strongly suggest a role of PAF as an important mediator of gastric damage after burn injury through its potent vasoactive effect on gastric microcirculation.