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Cardiovascular tolerance of mianserin and interactions of mianserin with other drugs

Cardiovascular tolerance of mianserin and interactions of mianserin with other drugs

Acta Psychiatrica Belgica 78(5): 787-797

The presented data clearly show that mianserin, which is therapeutically equal to other antidepressants, is a drug with a new chemical structure, with a most probably different mechanism of action and with distinct advantages above comparative drugs. Mianserin has not only pronouncedly fewer anticholinergic and central side-effects but: a) apparently has no cardiotoxic effects neither on healthy subjects nor on depressive individuals nor on cardiac patients; b) doses not cause orthostatic hypotension; c) is devoid of adverse drug-drug interactions with coumarin-like anticoagulants, with sympathomimetic amines, with antihypertensive agents and shows but little and short lasting interactions with alcohol.

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Accession: 039463720

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PMID: 375683

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