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Cell autonomy of lin-12 function in a cell fate decision in C. elegans

Cell autonomy of lin-12 function in a cell fate decision in C. elegans

Cell 57(7): 1237-1245

ISSN/ISBN: 0092-8674

PMID: 2736627

DOI: 10.1016/0092-8674(89)90060-3

The lin-12 gene of C. elegans encodes a predicted transmembrane protein that controls a decision by two cells, Z1.ppp and, between the anchor cell (AC) and ventral uterine precursor cell (VU) fates. We performed laser ablation experiments to demonstrate that specification of the VU fate of Z1.ppp or depends on an "AC-to-VU" signal from the presumptive AC. We generated genetic mosaics in which defined cells lacked lin-12 activity. By correlating the fates of Z1.ppp and with the lin-12 genotype of nearly every cell in these mosaics, we conclude that lin-12 function is VU cell autonomous. We present a model in which lin-12 functions in the receiving mechanism for the "AC-to-VU" signal leading to the specification of the AC and VU fates of Z1.ppp and

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Accession: 039479799

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