Changes in the adaptive cytoprotection and its relation to endogenous prostaglandins in rats with gastric mucosal atrophy

Wang, J.Y.; Wang, C.C.; Li, Z.J.; Yang, S.J.

Sheng Li Xue Bao 39(1): 10-18


ISSN/ISBN: 0371-0874
PMID: 3299723
Accession: 039504785

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The change of adaptive cytoprotection and its relation to endogenous prostaglandin E (PGE), prostacyclin (PGI2) and thromboxane A2 (TXA2) have been studied in rats with gastric mucosal atrophy produced by gamma irradiation to the stomach area. Pepsin 150 U in 0.1 mol/L HCl and 20% ethanol used as mild irritants were intragastrically given 15 min before administration of 80 m mol/L acidified taurocholate sodium in irradiated rats and the adaptive cytoprotection induced by them became significantly weaker. Twenty eight days after exposure to gamma irradiation, the ability of gastric mucosa to the formation of PGE and PGI2 was decreased and the generation of TXA2 was increased. After administration of mild irritants such as pepsin (in 0.1 mol/L HCl) or 20% ethanol to irradiated rats, the increasing level of PGE and PGI2 formed by gastric mucosa was lesser and the PGI2/TXA2 was lower than that in normal animals. Exogenous PGE2 (500 .mu.g/kg wt) given subcutaneously 5 min before the necrotizing agent restored the decreased state of the adaptive cytoprotection produced by irradiaton after pepsin 150 U in 0.1 mol/L HCl. These results indicate that the adaptive cytoprotection becomes weaker in rats with gastric mucosa atrophy and the mechanism responsible for these changes of protection is probably the reduction of PGs synthesis and the decrease of PGI2/TXA2 ratio in the gastric mucosa.