Home
  >  
Section 40
  >  
Chapter 39,506

Changes in the concentration of lipoprotein-X during incubation of postheparin plasma from patients with familial lecithin: cholesterol acyltransferase (LCAT) deficiency

Ritland, S.; Stokke, K.T.; Gjone, E.

Clinica Chimica Acta; International Journal of Clinical Chemistry 67(1): 63-69

1976

ISSN/ISBN: 0009-8981
PMID: 815065
Accession: 039505457
Download citation:  
Text
  |  
BibTeX
  |  
RIS
The concentration of lipoprotein-X (LP-X) has been studied in six patients with familial lecithin:cholesterol acyltransferase (LCAT) deficiency before and after the administration of heparin. In preheparin plasma, LP-X was present in all the patients, the concentrations ranging from 40 to 251 mg/100 ml. When postheparin plasma samples were incubated at 37 degrees C for 4 hours, LP-X could not be detected, whereas it was still present before incubation. LCAT activity was absent in the preheparin as well as in the postheparin samples. Accordingly, the changes in the concentration of LP-X could not be attributed to alterations in plasma LCAT activity. An increase in lysolecithin and a decrease in lecithin was observed during incubation of postheparin plasma samples.

PDF emailed within 1 workday: $29.90




Related References

Norum, K.R.; Glomset, J.A.; Nichols, A.V.; Forte, T.; Albers, J.J.; King, W.C.; Mitchell, C.D.; Applegate, K.R.; Gong, E.L.; Cabana, V. 1975: Plasma lipoproteins in familial lecithin: cholesterol acyltransferase deficiency: effects of incubation with lecithin: cholesterol acyltransferase in vitro Scandinavian Journal of Clinical and Laboratory Investigation. Supplementum 142: 31-55
Norum, K R.; Glomset, J A.; Nichols, A V.; Forte, T; Albers, J J.; King, W C.; Mitchell, C D.; Applegate, K R.; Gong, E L.; Cabana, V; Gjone, E 1975: Plasma Lipoproteins in Familial Lecithin:Cholesterol Acyltransferase Deficiency: Effects of Incubation with Lecithin: Cholesterol Acyltransferase in vitro Scandinavian Journal of Clinical and Laboratory Investigation 35(S142): 31-55
Murano, S.; Shirai, K.; Saito, Y.; Yoshida, S.; Ohta, Y.; Yamamoto, S.; Tsuchida, H. 1987: Impaired intermediate-density lipoprotein triglyceride hydrolysis in familial lecithin : cholesterol acyltransferase (Lcat) deficiency Nihon Naika Gakkai Zasshi 76(1): 123-127
Murano, S.; Shirai, K.; Saito, Y.; Yoshida, S.; Ohta, Y.; Tsuchida, H.; Yamamoto, S.; Asano, G.; Chen, C.H.; Albers, J.J. 1987: Impaired intermediate-density lipoprotein triglyceride hydrolysis in familial lecithin:cholesterol acyltransferase (LCAT) deficiency Scandinavian Journal of Clinical and Laboratory Investigation 47(8): 775-783
Murano, S.; Shirai, K.; Saito, Y.; Yoshida, S.; Ohta, Y.; Yamamoto, S.; Tsuchida, H. 1987: Impaired intermediate-density lipoprotein triglyceride hydrolysis in familial lecithin: cholesterol acyltransferase (LCAT) deficiency Nihon Naika Gakkai Zasshi. Journal of the Japanese Society of Internal Medicine 76(1): 123-127
Sakuma, M.; Akanuma, Y.; Kodama, T.; Yamada, N.; Murata, S.; Murase, T.; Itakura, H.; Kosaka, K. 1982: Familial plasma lecithin: cholesterol acyltransferase deficiency. a new family with partial LCAT activity Acta Medica Scandinavica 212(4): 225-232
Bérard, A.M.; Clerc, M.; Brewer, B.; Santamarina-Fojo, S. 2001: A normal rate of cellular cholesterol removal can be mediated by plasma from a patient with familial lecithin-cholesterol acyltransferase (LCAT) deficiency Clinica Chimica Acta; International Journal of Clinical Chemistry 314(1-2): 131-139
Godin, D.V.; Frohlich, J. 1981: Erythrocyte alterations in praseodymium-induced lecithin:cholesterol acyltransferase (LCAT) deficiency in the rat: comparison with familial LCAT deficiency in man Research Communications in Chemical Pathology and Pharmacology 31(3): 555-566
Bujo, H.; Saito, Y. 1995: Lecithin: cholesterol acyltransferase (LCAT)--the genetic analysis of familial LCAT deficiency and fish eye disease Nihon Rinsho. Japanese Journal of Clinical Medicine 53(5): 1260-1266
Park, C.W.; Lim, M.-H.; Youn, D.-Y.; Jung, S.E.; Chung, S.; Ahn, Y.S.; Chang, Y.S.; Lee, J.-H. 2009: Two novel frame shift mutations in lecithin:cholesterol acyltransferase (LCAT) gene associated with a familial LCAT deficiency phenotype Atherosclerosis 206(2): 346-348
Bender, B.U.; Quaschning, T.; Neumann, H.P.H.; Schmidt, D.; Kraemer-Guth, A. 2007: A novel frameshift mutation of the lecithin:cholesterol acyltransferase (LCAT) gene associated with renal failure in familial LCAT deficiency Clinical Chemistry and Laboratory Medicine 45(4): 483-486
Blomhoff, J.P.; Holme, R.; Sauar, J.; Gjone, E. 1978: Familial lecithin:cholesterol acyltransferase deficiency. Further studies on plasma lipoproteins and plasma postheparin lipase activity of a patient with normal renal function Scandinavian Journal of Clinical and Laboratory Investigation. Supplementum 150: 177-182
Blomhoff, J P.; Holme, R; Sauar, J; Gjone, E 1978: Familial Lecithin: Cholesterol Acyltransferase Deficiency Further Studies on Plasma Lipoproteins and Plasma Postheparin Lipase Activity of a Patient with Normal Renal Function Scandinavian Journal of Clinical and Laboratory Investigation 38(Sup 150): 177-182
Takata, K.; Kajiyama, G.; Horiuchi, I.; Watanabe, T.; Tokumo, H.; Hirata, Y. 1989: A new case of familial lecithin: cholesterol acyltransferase (LCAT) deficiency--paradoxical findings regarding LCAT mass and activity in 23 members of a family Japanese Journal of Medicine 28(6): 765-771
Guerin, M.; Dachet, C.; Goulinet, S.; Chevet, D.; Dolphin, P.J.; Chapman, M.J.; Rouis, M. 1997: Familial lecithin:cholesterol acyltransferase deficiency: molecular analysis of a compound heterozygote: LCAT (Arg147 --> Trp) and LCAT (Tyr171 --> Stop) Atherosclerosis 131(1): 85-95
Seidel, D.; Gjone, E.; Blomhoff, J.P.; Geisen, H.P. 1974: Plasma lipoproteins in patients with familial plasma lecithin: cholesterol acyltransferase (LCAT) deficiency--studies on the apolipoprotein composition of isolated fractions with identification of LP-X Hormone and Metabolic Research 4: 6-11
Dorval, I.; Jezequel, P.; Dubourg, C.; Chauvel, B.; Le Pogamp, P.; Le Gall, J.Y. 1994: Identification of the homozygous missense mutation in the lecithin:cholesterol-acyltransferase (LCAT) gene, causing LCAT familial deficiency in two French patients Atherosclerosis 105(2): 251-252
Hovig, T.; Gjone, E. 1973: Familial plasma lecithin: cholesterol acyltransferase (LCAT) deficiency. Ultrastructural aspects of a new syndrome with particular reference to lesions in the kidneys and the spleen Acta Pathologica et Microbiologica Scandinavica. Section A Pathology 81(5): 681-697
Subbaiah, P.V.; Pritchard, P.H.; Bagdade, J.D. 1988: Molecular species of lecithin in familial lecithin cholesterol acyltransferase lcat deficiency Arteriosclerosis 8(5): 582A
Chen, C.H.; Albers, J.J. 1982: Distribution of lecithin-cholesterol acyltransferase (LCAT) in human plasma lipoprotein fractions. Evidence for the association of active LCAT with low density lipoproteins Biochemical and Biophysical Research Communications 107(3): 1091-1096