Section 40
Chapter 39,546

Chromosomal localization of human gene for histidyl-tRNA synthetase: clustering of genes encoding aminoacyl-tRNA synthetases on human chromosome 5

Wasmuth, J.J.; Carlock, L.R.

Somatic Cell and Molecular Genetics 12(5): 513-517


ISSN/ISBN: 0740-7750
PMID: 3464104
DOI: 10.1007/bf01539922
Accession: 039545676

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The gene encoding histidyl-tRNA synthetase was localized to human chromosome 5 using human-Chinese hamster ovary cell hybrids. Seven of the functionally related genes encoding the 20 different aminoacyl-tRNA synthetases have not been mapped in humans and four are located on a single chromosome, number 5, which represents less than 7% of the total genome. Thus, there appears to be significant clustering of this group of genes which may reflect their evolutionary relatedness or common factors involved in regulating their expression.

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