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Chronic L-deprenyl does not alter the restoration of striatal dopamine in MPTP-lesioned mice



Chronic L-deprenyl does not alter the restoration of striatal dopamine in MPTP-lesioned mice



Journal of Neuroscience Research 23(3): 326-329



The present study examined the effect of chronic L-deprenyl on dopaminergic terminal function after mouse striatal terminals were lesioned with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP; 2 x 30 mg/kg s.c.). In the MPTP-lesioned mice, the level of dopamine was decreased by 59% 1 week after MPTP administration and by 22% at 16 weeks. Chronic administration of L-deprenyl (0.1 mg/kg, once weekly for up to 16 weeks) did not alter striatal dopamine metabolism, although monoamine oxidase B activity was reduced by 50% during this 16-week period, and did not alter the rate of restoration of the level of striatal dopamine.

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Accession: 039547156

Download citation: RISBibTeXText

PMID: 2504936

DOI: 10.1002/jnr.490230312


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