+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Chronic L-deprenyl does not alter the restoration of striatal dopamine in MPTP-lesioned mice

Chronic L-deprenyl does not alter the restoration of striatal dopamine in MPTP-lesioned mice

Journal of Neuroscience Research 23(3): 326-329

The present study examined the effect of chronic L-deprenyl on dopaminergic terminal function after mouse striatal terminals were lesioned with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP; 2 x 30 mg/kg s.c.). In the MPTP-lesioned mice, the level of dopamine was decreased by 59% 1 week after MPTP administration and by 22% at 16 weeks. Chronic administration of L-deprenyl (0.1 mg/kg, once weekly for up to 16 weeks) did not alter striatal dopamine metabolism, although monoamine oxidase B activity was reduced by 50% during this 16-week period, and did not alter the rate of restoration of the level of striatal dopamine.

Please choose payment method:

(PDF emailed within 0-6 h: $19.90)

Accession: 039547156

Download citation: RISBibTeXText

PMID: 2504936

DOI: 10.1002/jnr.490230312

Related references

The effects of chronic l deprenyl treatment on striatal dopamine levels in 1 methyl 4 phenyl 1 2 3 6 tetrahydroxypyridine lesioned mice. Annals of Neurology 28(2): 274, 1990

Novel sites of action for deprenyl in MPTP-parkinsonism: metabolite-mediated protection against striatal neurotoxicity and suppression of MPTP-induced increase of dopamine turnover in C57BL mice. Progress in Brain Research 106: 155-171, 1995

Striatal extracellular dopamine levels and behavioural reversal in MPTP-lesioned mice. Neuroreport 20(5): 482-486, 2009

FGF-2 modulates dopamine and dopamine-related striatal transmitter systems in the intact and MPTP-lesioned mouse. European Journal Of Neuroscience. 5(7): 927-932, 1993

Effect of deprenyl on mao activity and monoamine levels in different brain regions of aging mptp lesioned mice. Society for Neuroscience Abstracts 15(2): 1232, 1989

L-deprenyl in prevention of MPTP induced depletion of striatal enkephalins in mice. Chinese Medical Journal 101(4): 292-294, 1988

Levo deprenyl alters guinea pig striatal dopamine da metabolism but does not alter extracellular da levels. Society for Neuroscience Abstracts 17(1-2): 89, 1991

In vivo changes in striatal binding of dopamine uptake inhibitor fluorine 18 labelled gbr 13119 and muscarinic receptor ligand carbon 11 labelled 2a tropanylbenzilate in mptp lesioned c57bl 6 mice dual tracer injection studies. Society for Neuroscience Abstracts 15(1): 39, 1989

Rescue of dying neurons by (R)-deprenyl in the MPTP-mouse model of Parkinson's disease does not include restoration of neostriatal dopamine. Annals of the new York Academy of Sciences 939: 330-339, 2001

Mice lacking alpha-synuclein have an attenuated loss of striatal dopamine following prolonged chronic MPTP administration. Neurotoxicology 25(5): 761-769, 2004

Pattern of levodopa-induced striatal changes is different in normal and MPTP-lesioned mice. Journal of Neurochemistry 84(6): 1246-1255, 2003

Increased striatal neuropeptide Y immunoreactivity and its modulation by deprenyl, clonidine and L-dopa in MPTP-treated mice. Journal of Neural Transmission 110(12): 1375-1391, 2003