+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Clonazepam in the treatment of epilepsy. A controlled clinical trial in simple absences, bilateral massive epileptic myoclonus, and atonic seizures



Clonazepam in the treatment of epilepsy. A controlled clinical trial in simple absences, bilateral massive epileptic myoclonus, and atonic seizures



Archives of Neurology 33(5): 322-325



In a controlled clinical investigation based on ten patients with simple absences and ten patients with myoclonic atonic seizures, all patients who had insufficient response to conventional antiepileptic treatment received clonazepam (Rivotril [Denmark]; Clonopin, comparable US product) combined with previous antiepileptic drugs. The effects of the combined use of clonazepam and the previous antiepileptid drugs were compared with the effects of placebo combined with the same drugs. The trial was single-blind crossover with sequential analysis. In a daily dose of usually 3 to 6 mg, depending on patient age, the antiepileptic effect of clonazepam was significantly superior to placebo and was estimated as remarkably good. Side-effects of somnolence, fatigue, drowsiness, and coordination disturbances occurred in most of the patients, but subsided spontaneously or could be controlled by slow increase or slight reduction of dosage. Mental sideeffects such as agitation, confusion, and aggressiveness were more troublesome and caused discontinuation of clonazepam in two patients.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 039589046

Download citation: RISBibTeXText

PMID: 817696


Related references

Clinical features of epileptic seizures and epilepsy syndromes Symptoms of epileptic seizures forms according to the ILAE scheme Simple focal seizures. Froescher, W. , Vassella, F. Die Epilepsien: Grundlagen, Klinik, Behandlung. 145-152,, 1994

Clinical features of epileptic seizures and epilepsy syndromes Symptoms of epileptic seizures forms according to the ILAE scheme Unclassifiable epileptic seizures. Froescher, W. , Vassella, F. Die Epilepsien: Grundlagen, Klinik, Behandlung. 168-172,, 1994

Clinical features of epileptic seizures and epilepsy syndromes Epilepsies and epileptic syndromes Generalized epilepsies Idiopathic age-related generalized epilepsies Epilepsy with pyknoleptic absences. Froescher, W. , Vassella, F. Die Epilepsien: Grundlagen, Klinik, Behandlung. 200, 1993, 1994

Epileptic spasms in epilepsy with myoclonic-atonic seizures (Doose syndrome). Epileptic Disorders 18(3): 289-296, 2016

Myoclonic seizures, epileptic negative myoclonus, and atypical seizures in localization-related epilepsy. Epilepsia 37(Suppl. 3): 82-83, 1996

Clinical features of epileptic seizures and epilepsy syndromes Symptoms of epileptic seizures forms according to the ILAE scheme Generalized seizures. Froescher, W , Vassella, F [Epilepsies: Fundamentals, clinical features, treatment] Die Epilepsien: Grundlagen, Klinik, Behandlung 158-168, 1993, 1994

A controlled trial on clonazepam INN (Ro 5-4023, Rivotril (R)) in the treatment of focal epilepsy and secondary generalized grand mal epilepsy. Acta Neurologica Scandinavica. Supplementum 60: 55-61, 1975

Epileptic seizures, epilepsy and epileptic syndromes in newborns: a nosological approach to 94 new cases by the 2001 proposed diagnostic scheme for people with epileptic seizures and with epilepsy. Seizure 14(5): 304-311, 2005

Clonazepam in the treatment of panic disorder: a double-blind, placebo-controlled trial investigating the correlation between clonazepam concentrations in plasma and clinical response. Journal of Clinical Psychopharmacology 14(2): 111-118, 1994

A controlled trial on Ro 5-4023 (clonazepam) in the treatment of psychomotor epilepsy. Acta Neurologica Scandinavica. Supplementum 53: 18-25, 1973

Clinical features of epileptic seizures and epilepsy syndromes Symptoms of epileptic seizures forms according to the ILAE scheme Focal seizures with complex symptoms. Froescher, W , Vassella, F [Epilepsies: Fundamentals, clinical features, treatment] Die Epilepsien: Grundlagen, Klinik, Behandlung 152-158, 1993, 1994

Treatment options for epileptic myoclonus and epilepsy syndromes associated with myoclonus. Expert Opinion on PharmacoTherapy 10(10): 1549-1560, 2009

Clinical features of epileptic seizures and epilepsy syndromes Epilepsies and epileptic syndromes Epilepsies with generalized and focal seizures Epilepsy with continuous spike-wave discharges during sleep. Froescher, W , Vassella, F [Epilepsies: Fundamentals, clinical features, treatment] Die Epilepsien: Grundlagen, Klinik, Behandlung 252-256, 1993, 1994

Outpatient video EEG recording in the diagnosis of non-epileptic seizures: a randomised controlled trial of simple suggestion techniques. Journal of Neurology, Neurosurgery, and Psychiatry 72(4): 549-551, 2002

Clonazepam in the treatment of absence seizures a double blind clinical trial. Neurology 27(4): 371, 1977