+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Comparative Chemotherapeutical studies on the effect of Bactrim and other combined preparations on the proliferative and cystforming phase of Toxoplasma gondii in NMRI mice. A contribution to experimental chemotherapy of toxoplasmosis



Comparative Chemotherapeutical studies on the effect of Bactrim and other combined preparations on the proliferative and cystforming phase of Toxoplasma gondii in NMRI mice. A contribution to experimental chemotherapy of toxoplasmosis



Zentralblatt für Bakteriologie Parasitenkunde Infektionskrankheiten und Hygiene. Erste Abteilung Originale. Reihe A: Medizinische Mikrobiologie und Parasitologie 231(1-3): 349-364



In the present paper, the efficacy of different sulphonamides and potentiators alone and in combination (BACTRIM, FANSIDAR) in mice infected with Toxoplasma gondii is evaluated. The experimental chemotherapeutical studies were performed in mice either freshly infected with trophozoites or cystozoites, or suffering from acute disease or a chronic infection; For the components (see article) a proportion of 10 times 1 turned out to be the most effective mixing ratio. In comparison with the standard combination of sulphamethoxypyrazine times pyrimethamine sharing the best degree of activity, the therapeutic effect of a combination of sulphadoxine times pyrimethamine (components of FANSIDAR) in a proportion of 20 times 1 was either the same or less, depending on the experimental design. The duration of therapy was found to be decisive for the therapeutic result. If it is too short the parasite will return to the cyst stage; Even at low dosage, the components of FANSIDAR, sulphadoxine and pyrimethamine in combination, are capable of acting upon all forms of the proliferative multiplication phase and the cyst formation phase, inclusive of young cysts, and eliminated them completely from the host organism.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 039614332

Download citation: RISBibTeXText

PMID: 1154912


Related references

Comparative chemotherapeutical studies on the effect of combined preparations on the proliferative and cyst-forming phase of Toxoplasma gondii in NMRI mice. A contribution to the experimental chemotherapy of toxoplasmosis. Zentralblatt fur Bakteriologie, Parasitenkunde, Infektionskrankheiten und Hygiene, Abteilung 1 Originale, A 231: 349-364, 1975

Effect of ultra-long-acting sulphonamide, sulphamethoxypyrazine (Longum-Kelfizina) on the proliferative phase of replication of Toxoplasma gondii in NMRI mice. Contribution to experimental chemotherapy of toxoplasmosis. Zentralblatt für Bakteriologie Parasitenkunde Infektionskrankheiten und Hygiene. Erste Abteilung Originale. Reihe A: Medizinische Mikrobiologie und Parasitologie 222(1): 126-141, 1972

Experimental study of the activity of the sulphamethoxypyrazine (Longum equals Kelfizina) with pyrimethamine (Daraprim) on the cysts development phase of Toxoplasma gondii in Mastomys natalensis. Further contribution to experimental chemotherapy of toxoplasmosis. Zentralblatt für Bakteriologie Parasitenkunde Infektionskrankheiten und Hygiene. Erste Abteilung Originale. Reihe A: Medizinische Mikrobiologie und Parasitologie 226(4): 554-560, 1974

Studies on the therapeutics of experimental toxoplasmosis. I. Effect of acetylspiramycin and spiramycin on the intracardiac Toxoplasma multiplication in mice infected with Toxoplasma gondii. Japanese Journal of Antibiotics 34(8): 1141-1147, 1981

Studies on the therapeutics of experimental toxoplasmosis. II. Effect of acetylspiramycin alone or in combination with an immunopotentiator (CSP-II) or sulfamethopyrazine on Toxoplasma multiplication in the heart of mice acutely and chronically infected with Toxoplasma gondii. Japanese Journal of Antibiotics 35(2): 362-368, 1982

Experimental studies of the activity of certain drugs on zoites and cyst development of toxoplasma gondii in NMRI mice. Zeitschrift für Tropenmedizin und Parasitologie 23(1): 63-77, 1972

Experimental contribution to congenital toxoplasmosis. 3. communication. On the infection of trophoblasts through Toxoplasma gondii in mice. Zentralbl Bakt Parasitenk Infektionskrankh U Hyg 180(1): 118-135, 1960

Experimental study of the activity of the sulfamethoxy pyrazine with pyrimethamine on the cyst development phase of toxoplasma gondii in mastomys natalensis further contribution to experimental chemo therapy of toxoplasmosis. Zentralblatt Fuer Bakteriologie Parasitenkunde Infektionskrankheiten Und Hygiene Erste Abteilung Originale Reihe A Medizinische Mikrobiologie Und Parasitologie: 554-560, 1974

Comparative effect of corynebacterium parvum and glucan on serum protein, antibody synthesis, spleen weight and resistance against virulent toxoplasma gondii RH in NMRI mice. International Journal of Immunopharmacology 2(3): 177-0, 1980

The effect of chemo-immunotherapy with SDDS, pyrimethamine and anti-toxoplasma serum on toxoplasma gondii cysts in latent infected NMRI mice. Tropenmedizin und Parasitologie 28(4): 528-532, 1977

On the effect of SDDS in combination with pyrimethamine or sulfamonomethoxine on cysts of Toxoplasma gondii in NMRI mice. Tropenmedizin und Parasitologie 25(3): 313-317, 1974

Immunization of nmri mice against virulent toxoplasma gondii differing efficacy of 11 cyst forming toxoplasma strains. Zeitschrift fuer Parasitenkunde 54(3): 209-216, 1977

Criteria of Efficacy of Chemotherapeutic Substances in Experimental Toxoplasmosis and the Therapeutic Effect of the Spiramycin-Sulfamethoxydiazine Combination in White Mice Inoculated with "toxoplasma Gondii". La Presse Medicale 72: 1125-1128, 1964

Immunization of NMRI mice against virulent Toxoplasma gondii. Differing efficacy of eleven cyst-forming Toxoplasma strains. Zeitschrift fur Parasitenkunde 54(3): 209-216, 1977

Experimental study of the activity of ultra long sulfonamide sulfamethoxypyrazine kelfizina and pyrimethamine daraprim on cystozoites and cyst development of toxoplasma gondii in nmri mice. Papaevangelou, George J Ninth International Congress on Tropical Medicine And Malaria, Vol Ii Abstracts Of Communications Athens, Greece, October 14-21, 219p Congress Publications Committee: Athens, Greece 149, 1973