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Comparative alpha- and beta-adrenoceptor activity of 2- and 6-ring-chlorinated noradrenaline analogues

Comparative alpha- and beta-adrenoceptor activity of 2- and 6-ring-chlorinated noradrenaline analogues

Arzneimittel-Forschung 36(3): 457-460

The alpha- and beta-adrenoceptor activity of the 2- and 6-ring-chlorinated analogues of noradrenaline (norepinephrine) were evaluated in vitro. The 2-chloro-substituted analogue exhibits a far greater affinity for beta 1-chronotropic receptors than the 6-chloro-substituted analogue, whereas no significant differences are apparent for their alpha-adrenergic affinities.

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Accession: 039614547

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PMID: 3011022

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