+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Comparative analgesic efficacy and tolerability of ketorolac tromethamine and glafenine in patients with post-operative pain

Comparative analgesic efficacy and tolerability of ketorolac tromethamine and glafenine in patients with post-operative pain

Current Medical Research and Opinion 11(4): 214-220

In a randomized, single-dose, double-blind, parallel comparative trial of analgesic efficacy, 96 adult patients received either 10 mg ketorolac tromethamine or 400 mg glafenine orally the morning after surgery if they requested pain relief medication. Each patient provided a baseline pain assessment and then received the assigned medication. Patients assessed pain intensity and pain relief and reported any adverse events in interviews held 30 minutes after drug administration and then hourly for 6 hours. The demographic characteristics, baseline pain intensity, and surgical categories of the 47 patients who received ketorolac tromethamine and the 49 who received glafenine were similar. Both drugs provided prompt, sustained pain relief throughout the 6-hour observation period, and there were no statistically significant differences between the two groups in any of the efficacy measures analyzed. The global assessment recorded by patients suggested a slight clinical advantage for ketorolac tromethamine (32.6% of 'excellent' responses) as compared to glafenine (12.5% 'excellent'). The differences in overall response were statistically significant (p = 0.017). Fourteen (30%) patients who received ketorolac tromethamine and 17 (35%) who received glafenine reported adverse experiences that began or seemed to worsen after administration of the study drugs. The most prominent were drowsiness and sleeping, both of which are common in post-surgical patients.

Please choose payment method:

(PDF emailed within 0-6 h: $19.90)

Accession: 039614557

Download citation: RISBibTeXText

PMID: 2905636

DOI: 10.1185/03007998809114238

Related references

Analgesic efficacy and safety comparison of ketorolac tromethamine and doleron for the alleviation of orthopedic post operative pain. Journal of International Medical Research 17(4): 324-332, 1989

Comparative study of the analgesic activity of glafenine and a paracetamol-codeine combination in post-operative dental pain. Bulletin du Groupement International Pour la Recherche Scientifique en Stomatologie and Odontologie 27(1): 53-64, 1984

Analgesic efficacy and safety of single-dose oral and intramuscular ketorolac tromethamine for postoperative pain. PharmacoTherapy 10(6 ): 59s-70s, 1990

Systematic review of the analgesic efficacy and tolerability of COX-2 inhibitors in post-operative pain control. Journal of Clinical Pharmacy and Therapeutics 29(3): 215-229, 2004

Effect of pretreatment with ketorolac tromethamine on post-operative pain following periodontal surgery. Journal of Clinical Periodontology 23(2): 128-132, 1996

Double-blind placebo-controlled study of the effectiveness and tolerability of 10 and 30 mg ketorolac tromethamine suppositories in post-cholecystectomy pain. Minerva Anestesiologica 60(9): 443-449, 1994

A multiinstitutional evaluation of the analgesic efficacy and safety of ketorolac tromethamine, acetaminophen plus codeine, and placebo in cancer pain. PharmacoTherapy 10(3): 211-216, 1990

Single-blind comparative analgesic and safety study of single doses of intramuscularly administered ketorolac tromethamine and pethidine hydrochloride in patients with pain following orthopaedic surgery. Annals of the Academy of Medicine Singapore 23(6): 828-831, 1994

Efficacy of ketorolac tromethamine and extrapleural intercostal nerve block on post-thoracotomy pain. International Surgery 82(3): 322, 1997

Efficacy of ketorolac tromethamine and extrapleural intercostal nerve block on post-thoracotomy pain. A prospective, randomized study. International Surgery 81(3): 224-228, 1996

Ketorolac tromethamine improves the analgesic effect of hyoscine butylbromide in patients with intense cramping pain from gastrointestinal or genitourinary origin. Arzneimittel-Forschung 62(12): 603-608, 2013

The Analgesic Effect of Ketorolac Tromethamine in Cancer Pain. Zhongguo Zhongliu Linchuang 22(1): 43-44, 1995

Safety and efficacy of ketorolac tromethamine 0.4% ophthalmic solution in post-photorefractive keratectomy patients. Journal of Cataract and Refractive Surgery 30(8): 1653-1660, 2004

Safety and efficacy of reformulated ketorolac tromethamine 04% ophthalmic solution in post photorefractive keratectomy patients. ARVO Annual Meeting Abstract Search & Program Planner : Abstract No 2611, 2003