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Comparative analysis of disorders of neuromuscular conduction in patients with botulism and Eaton-Lambert myasthenic syndrome



Comparative analysis of disorders of neuromuscular conduction in patients with botulism and Eaton-Lambert myasthenic syndrome



Zhurnal Nevropatologii i Psikhiatrii Imeni S.S. Korsakova 89(3): 102-107



The analysis of conduction at neuromuscular junctions was performed in 25 patients with botulism and 31 patients with Lambert-Iton syndrome. These groups showed apparent differences in mechanisms of recruitment and posttetanic facilitation of the neurotransmitter release. Prolonged stimulation with the rate of 6 imp/s in ischemic muscles pointed to essential differences in the mechanisms facilitating the transmitter release. These differences of neuromuscular conduction disorders in botulism and Lambert-Iton syndrome are supposedly connected with affliction of different mechanisms of conduction facilitation in the neuromuscular synapses.

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Accession: 039614668

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PMID: 2543168


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