+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Comparative analysis of enzyme activities in endomyocardial biopsy samples of patients with various cardiomyopathies



Comparative analysis of enzyme activities in endomyocardial biopsy samples of patients with various cardiomyopathies



Zeitschrift für Kardiologie 76(12): 744-750



41 patients have been investigated using invasive techniques including left ventricular endomyocardial biopsy. One of six specimens per patient was investigated biochemically. 8 pts. (group A) suffered from dilated cardiomyopathy (DCM), 13 (group B) from sarcoidosis of the lungs, 20 (group C) from so-called latent cardiomyopathy (LCM). The histological diagnoses were: normal (3 pts.), small vessel disease (4 pts.), unknown etiology (4 pts.), post myocarditis (6 pts.), residual myocarditis (12 pts.), active myocarditis (5 pts.), suspected toxic myocardial disease (6 pts.), Fabry's disease (1 pt.). The enzyme/isoenzyme activities of malate dehydrogenase (MDH), aspartate amino transferase (ASAT) and lactate dehydrogenase (LDH) were measured and compared in different hemodynamic and histologic groups. The enzyme activities from patients with impaired left ventricular function were increased. Independent from left ventricular function the activities of MDH, ASAT and LDH as well mitochondrial isoenzymes were decreased in active and residual myocarditis. The isoenzyme LDH M was increased significantly in active myocarditis and suspected toxic myocardial disease. The measurements of LDH enzyme/isoenzyme profile in myocardial tissue obtained by endomyocardial biopsy seem to support the histological diagnosis of active myocarditis.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 039614676

Download citation: RISBibTeXText

PMID: 3439249


Related references

Comparative analysis of enzyme activities in endomyocardial biopsy samples from patients with different heart muscle diseases. Zeitschrift fuer Kardiologie 76(12): 744-750, 1987

Upregulation of redox-regulating protein, thioredoxin, in endomyocardial biopsy samples of patients with myocarditis and cardiomyopathies. Molecular & Cellular Biochemistry 248(1-2): 193-196, 2003

Enzymic analysis of endomyocardial biopsy specimens from patients with cardiomyopathies. British Heart Journal 39(12): 1333-1339, 1977

Comparative analysis of myocardial enzyme activities of the energy-supplying metabolism in patients with dilative cardiomyopathies and valve diseases. Clinical Cardiology 9(5): 197-202, 1986

Enzymatic activities of the mitochondrial respiratory chain in child cardiomyopathies. 34 cases prospectively studied by endomyocardial biopsy. Archives des Maladies du Coeur et des Vaisseaux 85(5): 541-546, 1992

Comparative analysis of the complications of 5347 endomyocardial biopsies applied to patients after heart transplantation and with cardiomyopathies: a single-center study. Transplantation Proceedings 44(8): 2473-2478, 2012

Interrelation of left ventricular function and myocardial ultrastructure as assessed by endomyocardial biopsy: comparative study of hypertrophic and congestive cardiomyopathies. Recent Advances in Studies on Cardiac Structure and Metabolism 12: 327-334, 1976

Contribution and risks of left ventricular endomyocardial biopsy in patients with cardiomyopathies: a retrospective study over a 28-year period. Circulation 128(14): 1531-1541, 2013

Enzymatic analysis and collagen content in endomyocardial biopsy samples of patients with congestive cardiomyopathy of unknown etiology. Clinical Cardiology 3(5): 329-334, 1980

Comparison of methods for library construction and short read annotation of shellfish viral metagenomes. Genes and Genomics 40(3): 281-288, 2018

Letter by Andreoletti et al regarding article, "contribution and risks of left ventricular endomyocardial biopsy in patients with cardiomyopathies: a retrospective study over a 28-year period". Circulation 130(4): E30-E30, 2014

Endomyocardial biopsy in diagnosis of cardiomyopathies. British Heart Journal 33(6): 822-832, 1971

Value of endomyocardial biopsy in the diagnosis of cardiomyopathies. Klinicheskaia Meditsina 67(8): 21-26, 1989

Frequency, extent, and distribution of endomyocardial adipose tissue: Morphometric analysis of endomyocardial biopsy specimens from 241 patients. Cardiovascular Pathology 3(1): 33-41, 1994

The role of endomyocardial biopsy in the diagnosis of cardiomyopathies. Italian Heart Journal 3(6): 348-353, 2002