+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Comparative analysis of long-term mortality after thrombolytic therapy

Comparative analysis of long-term mortality after thrombolytic therapy

American Journal of Cardiology 68(16): 38e

In patients with acute myocardial infarction, thrombolytic therapy has a demonstrable and favorable impact on a range of clinical indicators, including left ventricular function, infarct size, coronary arterial patency, and symptom relief. However, these indicators have not provided a reliable basis for the comparison of thrombolytic regimens; mortality provides the "gold standard." One-year mortality obviates the differences in the timing of short-term comparisons (in-hospital, 30-day, or 5-week). In addition, late effects of differences in patency, including the impact of reocclusion, infarct healing, and remodeling, will be evident by 1 year. Meta-analysis of data from previous major mortality studies shows that differences in design and the overlap of confidence intervals of mortality studies suggest that no thrombolytic agent is superior in terms of short-term mortality. Long-term survival may provide a more meaningful basis for comparison of efficacy of the thrombolytic regimens. Long-term mortality has been evaluated for anistreplase in acute myocardial infarction in a composite analysis, similar to a meta-analysis. From the pooled life table analysis of all anistreplase studies, the odds reduction in mortality at 1 year was approximately 48%.

Please choose payment method:

(PDF emailed within 0-6 h: $19.90)

Accession: 039614727

Download citation: RISBibTeXText

PMID: 1746451

DOI: 10.1016/0002-9149(91)90304-4

Related references

No mortality benefit of primary angioplasty over thrombolytic therapy in patients with nonanterior myocardial infarction at long-term follow-up Results of the zwolle Trial. Journal of the American College of Cardiology 41(6 Suppl. A): 369A, 2003

Long-term effect of intravenous thrombolytic therapy in acute stroke: responder analysis versus uniform analysis of excellent outcome. Cerebrovascular Diseases 20(6): 470-474, 2005

Is recurrent myocardial infarction following thrombolytic administration associated with long-term mortality?. Journal of the American College of Cardiology 39(5 Suppl. A): 280A, 2002

Long term follow up after thrombolytic therapy. European Heart Journal 8(ABSTR Suppl. 2): 48, 1987

Superiority of warfarin over asa long term after thrombolytic therapy. Clinical Research 36(3): 315A, 1988

Thrombolytic therapy for occlusion of long term catheters. Journal of the American College of Nutrition 8(5): 428, 1989

Mortality in a cohort of long term users of hormone replacement therapy an updated analysis. British Journal of Obstetrics and Gynaecology 97(12): 1080-1086, 1990

Which factors determine long term benefit after thrombolytic therapy?. European Heart Journal 10(ABSTR Suppl.): 197, 1989

Efficacy of thrombolytic therapy for occlusion of long-term catheters. Jpen. Journal of Parenteral and Enteral Nutrition 14(3): 312-314, 1990

An analysis of the cause of early mortality after administration of thrombolytic therapy. Coronary Artery Disease 4(11): 957-964, 1993

Acute hypercapnic respiratory failure (AHRF): looking at long-term mortality, prescription of long-term oxygen therapy and chronic non-invasive ventilation (NIV). Clinical Medicine 12(2): 188, 2012

Failure of thrombolytic therapy to improve long-term vascular patency. Journal Of Vascular Surgery. : 289-297, 1994

Long term results of thrombolytic therapy in myocardial infarction patients. European Heart Journal 11(ABSTR Suppl.): 353, 1990

Long-term efficacy of acute thrombolytic therapy for myocardial infarction. Internal Medicine 33(7): 387-395, 1994

Long-term results of thrombolytic therapy in acute myocardial infarct. Vnitrni Lekarstvi 33(7): 536-544, 1987