+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Comparative analysis of serum levels of CA-50, CA-125, CA-19.9, enolase and CEA in bronchopulmonary cancer



Comparative analysis of serum levels of CA-50, CA-125, CA-19.9, enolase and CEA in bronchopulmonary cancer



Revue de Pneumologie Clinique 43(5): 224-228



A serum assay of CA-50, CA-125, CA-19.9, ENOLASE (NSE) and CEA was performed in 65 patients with primary lung cancer, 63% of whom had visceral metastases, with the following histological distribution: squamous carcinoma (40), adenocarcinoma (9), large cell carcinoma (4), oat cell carcinoma (12). A raised CEA level was detected in 37% of cases, compared with 40.6% for CA-50, 44.6% for CA-19.9 and 40.6% for CA-125 and only 26.6% for NSE. Overall, at least one marker was positive in 83% of cases. Statistical analysis of the different markers (correlation analysis and principal component analysis) demonstrated the existence of a strict correlation between the levels of CA-50, CEA and CA-19.9 (p less than 0.01). ENOLASE was more frequently elevated in oat cell carcinomas (42%) than in non-oat cell carcinomas (30%), but the difference was not significant. In contrast, CA-125 appears to be a good marker for non-oat cell carcinomas (51%) (p less than 0.05). The authors also found a correlation between the presence of a raised level of CA-50 (p less than 0.05), CA-125 (p less than 0.02) and especially CEA (p less than 0.001) and the presence of visceral metastases. The initial survey of disseminated lung cancers should include the assay of at least 4 of these markers in order to obtain a reliable serum tracer in more than 2/3 of cases.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 039614800

Download citation: RISBibTeXText

PMID: 2829332


Related references

The value of measuring serum TPA levels in bronchopulmonary cancer: A comparative study with ACE, CA 19.9 and NSE levels. Revue des Maladies Respiratoires 11(4): 379-384, 1994

Diagnostic value of α-enolase expression and serum α-enolase autoantibody levels in lung cancer. Jornal Brasileiro de Pneumologia 44(1): 18-23, 2018

Serum NSE (neuron-specific enolase) levels in small cell lung cancer, with special reference to the measurement of serial serum NSE levels. Gan to Kagaku Ryoho. Cancer and ChemoTherapy 14(8): 2469-2474, 1987

Serum neuron-specific enolase levels were associated with the prognosis of small cell lung cancer: a meta-analysis. Tumour Biology 34(5): 3245-3248, 2013

Blood levels of CA-50, CA-19.9, CA-125, enolase, CA-15.3 and carcinoembryonic antigen in non-cancerous bronchopulmonary pathology. Revue des Maladies Respiratoires 5(6): 573-576, 1988

Relation between serum neuron-specific enolase and CEA levels in the patients with lung cancer. Zhonghua Jie he He Hu Xi Za Zhi 11(4): 219, 1988

Clinical evaluation of serum neuron-specific enolase levels in patients with lung cancer. Radioisotopes 36(2): 78-80, 1987

Serum neuron specific enolase (NSE) levels in patients with non small cell lung cancer. Nihon Kyobu Shikkan Gakkai Zasshi 30(6): 1097-1102, 1992

Enzymatic determination of serum neuron-specific enolase in small cell lung cancers. Utility of the serum neuron-specific enolase/serum nonneuronal enolase ratio. Chest 93(6): 1225-1233, 1988

Clinical significance of the measurement of serum neuron-specific enolase levels in patients with lung cancer. Gan to Kagaku Ryoho. Cancer and ChemoTherapy 13(6): 2089-2093, 1986

Clinical significance of serum neuron specific enolase (NSE) levels in patients with gastric and colorectal cancer. Rinsho Byori. Japanese Journal of Clinical Pathology 34(11): 1236-1240, 1986

Serum neuron specific enolase levels correlate with patient prognosis for advanced lung cancer. International Journal of Clinical and Experimental Medicine 8(6): 9498-9504, 2015

Neuron specific enolase calcitonin carcinoembryonic antigen and bombesin serum levels in lung cancer. Proceedings of the American Association for Cancer Research Annual Meeting 29: 179, 1988

Clinical evaluation of serum NSE (neuron specific enolase) levels in cases of small cell lung cancer. Rinsho Hoshasen. Clinical Radiography 33(1): 31-34, 1988

Cigarette smoking and serum levels of alpha-1 fetoprotein, carcinoembryonic antigen, cancer antigens 125 and 19-9, neurone-specific enolase. Medical Science Research 21(12): 445-446, 1993