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Comparative analysis of the variants of experimental intra-aural pharmacophysical intervention



Comparative analysis of the variants of experimental intra-aural pharmacophysical intervention



Vestnik Otorinolaringologii 1990(4): 17-20



The permeability of the blood-brain barrier of rabbits was measured in response to different methods of endaural pharmacophysical intervention and intravenous injection of radioactive DL (2,3-3H2) leucine. The concentration of labelled leucine was measured in the inner ear fluids. The experiments were performed using 28 rabbits. The maximum amount of the drug entered the labyrinth as a result of endaural superphonoelectrophoresis. In this case the positive effect was reached after a smaller number of therapeutic sessions. This method is recommended for clinical treatment of cochleovestibular lesions.

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Accession: 039614981

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PMID: 2238341


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