+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Comparison of insulin secretion and insulin sensitivity between normal and impaired glucose tolerance subjects with normal fasting plasma glucose



Comparison of insulin secretion and insulin sensitivity between normal and impaired glucose tolerance subjects with normal fasting plasma glucose



Zhonghua Yi Xue Za Zhi 46(2): 73-78



To examine glucose-stimulated insulin secretion and insulin sensitivity in the normal subjects and patients with impaired glucose tolerance, we performed the oral glucose tolerance test (OGTT) and modified insulin suppression test in 34 non-obese subjects. The plasma glucose and insulin concentrations were measured during fasting and every 30 min up to 120 min following 75 g of oral glucose loading. Ten subjects were classified as impaired glucose tolerance (IGT), and 24 subjects were as having normal glucose tolerance. In addition, the insulin-stimulated glucose uptake was estimated in all subjects by measuring the final 30 min steady-state plasma glucose (SSPG) of a continuous infusion of somatostatin, insulin and glucose for 4 hours (modified insulin suppression test). The mean plasma glucose concentrations of fasting and 60, 90, 120 min during OGTT study were significantly higher in the IGT subjects than in the normals. In addition, the mean incremental glucose areas under the curve during OGTT study were also greater in the IGT subjects than in the normals. The mean serum insulin concentrations were significantly higher at 90 and 120 minutes in the IGT patients than in the normals. During the modified insulin suppression test, the mean SSPG concentrations were significantly higher in the IGT patients than in the normals under the similar steady-state plasma insulin in both groups. There was a good correlation between the incremental insulin areas under the curve (OGTT) and the SSPG in the normal subjects (p less than 0.0001).

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 039630442

Download citation: RISBibTeXText

PMID: 2177367


Related references

Natural history of insulin sensitivity and insulin secretion in the progression from normal glucose tolerance to impaired fasting glycemia and impaired glucose tolerance: the Inter99 study. Diabetes Care 32(3): 439-444, 2009

Effects of weight loss in obese subjects with normal fasting plasma glucose or impaired glucose tolerance on insulin release and insulin resistance according to a minimal model analysis. Metabolism, Clinical and Experimental 53(9): 1095-1100, 2004

Assessment of insulin sensitivity and secretion indices from oral glucose tolerance testing in subjects with fasting euglycemia but impaired 2-hour plasma glucose. Metabolism: Clinical and Experimental 52(11): 1523-4; Discussion 1524-5, 2003

Effects of miglitol taken just before or after breakfast on plasma glucose, serum insulin, glucagon and incretin levels after lunch in men with normal glucose tolerance, impaired fasting glucose or impaired glucose tolerance. Journal of Diabetes Investigation 2(6): 435-440, 2011

Insulin secretion and insulin sensitivity pattern is different in isolated impaired glucose tolerance and impaired fasting glucose: the risk factor in Impaired Glucose Tolerance for Atherosclerosis and Diabetes study. Diabetes Care 26(3): 868-874, 2003

The relationship between fasting hyperglycemia and insulin secretion in subjects with normal or impaired glucose tolerance. American Journal of Physiology. Endocrinology and Metabolism 295(2): E401-E406, 2008

Diagnosis of hyperglycemia in a cohort of Brazilian subjects: fasting plasma glucose- and oral glucose tolerance test-based glycemic status are associated with different profiles of insulin sensitivity and insulin secretion. Diabetes Care 30(8): 2135-2137, 2007

Assessment of Insulin Resistance in Subjects with Normal Glucose Tolerance, Hyperinsulinemia with Normal Blood Glucose Tolerance, Impaired Glucose Tolerance, and Newly Diagnosed Type 2 Diabetes (Prediabetes Insulin Resistance Research). Journal of Diabetes Research 2016: 9270768, 2016

Insulin sensitivity and secretion indices in Japanese subjects with normal and impaired glucose tolerance. Diabetology International 3(2): 80-85, 2012

Differences in cardiovascular risk factors, insulin resistance, and insulin secretion in individuals with normal glucose tolerance and in subjects with impaired glucose regulation: the Telde Study. Diabetes Care 28(10): 2388-2393, 2005

Differences in insulin action and secretion, plasma lipids and blood pressure levels between impaired fasting glucose and impaired glucose tolerance in Japanese subjects. Hypertension Research 31(7): 1357-1363, 2008

Evaluation of antioxidative activity, insulin sensitivity and insulin secretion in early glucoregulation disorders-impaired fasting glucose and impaired glucose tolerance. Diabetes & Metabolism 29(Hors serie 2): 4S65, 2003

Indices of insulin sensitivity and secretion from a standard liquid meal test in subjects with type 2 diabetes, impaired or normal fasting glucose. Nutrition Journal 8: 22, 2009

Intravenous glucose tolerance, insulin response to glucose, peripheral sensitivity to insulin, and serum lipoproteins in post-myocardial infarct patients with normal fasting blood glucose. Hormone and Metabolic Research 16(8): 406-410, 1984

Insulin secretion and insulin resistance in impaired fasting glucose and impaired glucose tolerance subjects. Diabetologia 44(Suppl. 1): A 56, 2001