+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Comparison of insulin secretory patterns in obese nondiabetic LA/N-cp and obese diabetic SHR/N-cp rats. Role of hyperglycemia



Comparison of insulin secretory patterns in obese nondiabetic LA/N-cp and obese diabetic SHR/N-cp rats. Role of hyperglycemia



Diabetes 38(6): 691-697



Obese diabetic SHR/N-(cp/cp) rats are a genetic model for non-insulin-dependent diabetes mellitus. When SHR/N-cp rats are overtly diabetic, they are hyperinsulinemic and hyperglycemic in the fed state when consuming commercial chow or semipurified high-carbohydrate diets. Obese SHR/N-cp rats were hyperinsulinemic by 4 wk of age, although hyperglycemia did not appear until 3-4 wk later and was exacerbated by a high-sucrose diet (mean +/- SE 1488 +/- 238 microU/ml insulin and 425 +/- 51 mg/dl glucose). The control SHR/N-cp rats (+/?) on the sucrose diet remained lean and normoglycemic. The obese diabetic SHR/N-cp rats showed three alterations in pancreas perfusion data (not present in control rats): 1) paradoxically high insulin secretion at low glucose levels (2.5 mM), 2) secretion of insulin in response to arginine (10 mM) in the absence of glucose, and 3) impaired response of insulin secretion to high glucose (16.7 mM). To determine whether hyperglycemia was responsible for the abnormalities of insulin secretion, perfusion studies were conducted in obese nondiabetic LA/N-cp rats and compared with the SHR/N-cp rats. The obese LA/N-cp rats resembled the corpulent SHR/N-cp rats in every way, except that they were normoglycemic on the sucrose diet. The obese LA/N-cp rats had two of the three alterations in insulin secretion shown by obese SHR/N-cp rats, lacking only the impaired response to high glucose, suggesting that hyperglycemia was required for that defect to occur.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 039630443

Download citation: RISBibTeXText

PMID: 2656338

DOI: 10.2337/diab.38.6.691


Related references

The role of central fat distribution in coronary artery disease in obesity: comparison of nondiabetic obese, diabetic obese, and normal weight subjects. International Journal of Obesity and Related Metabolic Disorders 23(11): 1129-1135, 1999

Fluoxetine increases insulin action in obese nondiabetic and in obese non-insulin-dependent diabetic individuals. International Journal of Obesity and Related Metabolic Disorders 16(2): 79-85, 1992

Metformin normalizes insulin binding to monocytes from obese nondiabetic subjects and obese type II diabetic patients. Journal of Clinical Endocrinology and Metabolism 57(4): 713-718, 1983

Differential adipose tissue inflammatory state in obese nondiabetic Zucker fatty rats compared to obese diabetic zucker diabetic fatty rats. Hormone and Metabolic Research 44(4): 273-278, 2012

Comparison of the effects of sibutramine on insulin resistance and metabolic parameters in diabetic obese and non-diabetic obese patients. Diabetologia 45(Suppl. 2): A 219, 2002

A role for iNOS in fasting hyperglycemia and impaired insulin signaling in the liver of obese diabetic mice. Diabetes 54(5): 1340-1348, 2005

Glucose profiles insulin antibody levels and beta cell secretory patterns in non obese ugandan diabetic subjects. Diabetes Research & Clinical Practice 5(Suppl. 1): S508, 1988

Neonatal castration improves insulin sensitivity more in obese zucker than in obese wistar diabetic fatty rats. FASEB Journal 4(4): A918, 1990

Differences between metabolic responses to fasting in obese diabetic and obese nondiabetic subjects. Diabetes 20(4): 214-227, 1971

Role of serum adiponectin levels in the progression of insulin resistance and atherogenesis in obese and non-obese diabetic. Diabetes & Metabolism 29(Hors serie 2): 4S100-4S101, 2003

Hepatic iNOS and ST6Gall inflammatory markers are increased in obese diabetic but not in nondiabetic obese rat models. 2007

Serum levels of insulin in the normal subject (obese and non-obese) and in the obese diabetic after intragastric administration of amino acids. Acta Diabetologica Latina 5(1): 64-79, 1968

Insulin sensitivity, insulin action, and fibrinolysis activity in nondiabetic and diabetic obese subjects. Metabolism Clinical & Experimental 47(11): 1372-1375, 1998

Non insulin dependent diabetes mellitus in obese hyperglycemic mice in relation to feeding comparison with the human obese diabetic condition. Current Therapeutic Research 44(4): 612-618, 1988

A prospective study of glucose profiles, insulin antibody levels and beta cells secretory patterns in non-obese Ugandan diabetic subjects. East African Medical Journal 65(1): 8, 1988