+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Control of plasma aldosterone in infancy and childhood. A study of plasma renin activity, plasma cortisol and plasma aldosterone



Control of plasma aldosterone in infancy and childhood. A study of plasma renin activity, plasma cortisol and plasma aldosterone



Helvetica Paediatrica Acta 30(4-5): 349-356



In order to elucidate the main factors controlling plasma aldosterone in infancy and childhood, plasma renin activity (PRA), plasma cortisol (PC, as a parameter of ACTH activity), plasma aldosterone (PA) and serum sodium and potassium were measured simultaneously in 84 healthy children (62 recumbent, 22 upright) ranging in age from 6 days to 16 years. 10 healthy male students served as adult controls. As compared to the controls, PRA levels were significantly higher in the children up to the age of 12 years. PA was also elevated in most children; the highest values for PA and for PRA were observed during the first 4 years of life. A significant positive correlation between PRA and PA (n = 84, r = 0,62, p less than 0.001) was found. There were no significant differences in serum sodium or potassium or in PC. All PC values were - with one exception - within the range found in healthy adults. Our results indicate that high PA values are freuqently observed in healthy children. They are mainly caused by elevated PRA. The physiological significance of increased activation of the renin-angiotensin-aldosterone system in infancy is not yet clear.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 039682594

Download citation: RISBibTeXText

PMID: 1245434


Related references

The diurnal rhythm of plasma aldosterone, plasma renin activity, plasma cortisol and serum growth hormone and subnormal responsiveness of aldosterone to angiotensin-II in the patients with normotensive acromegaly. Endocrinologia Japonica 23(1): 75-82, 1976

The influence of aging on the renin angiotensin-aldosterone system: simultaneous measurement of plasma renin substrate concentration, plasma renin activity, plasma aldosterone concentration, and plasma active and inactive renin concentrations. Nihon Naika Gakkai Zasshi. Journal of the Japanese Society of Internal Medicine 73(9): 1304-1309, 1984

Diurnal variations of plasma aldosterone in supine man: relationship to plasma renin activity and plasma cortisol. Acta Endocrinologica 80(1): 95, 1975

Effect of aldosterone antagonist canrenone on plasma aldosterone concentration and plasma renin activity, and on the excretion of aldosterone and electrolytes by man. European Journal of Clinical Pharmacology 9(4): 253-257, 1976

Effects of excessive salt-loading on blood pressure, plasma norepinephrine concentration, plasma renin activity, plasma aldosterone concentration and urinary aldosterone excretion in patients with essential hypertension and normotensive subjects. Nihon Naika Gakkai Zasshi. Journal of the Japanese Society of Internal Medicine 72(1): 38-46, 1983

Study on renin-angiotensin-aldosterone system. I. Changes of plasma renin activity, plasma aldosterone concentration and urinary sodium excretion in normotensive subjects. Nihon Jinzo Gakkai Shi 26(2): 221-232, 1984

Study on renin-angiotensin-aldosterone system. II. Changes of plasma renin activity, plasma aldosterone concentration and urinary sodium excretion in the hypertensives. Nihon Jinzo Gakkai Shi 26(2): 233-242, 1984

Studies of diurnal changes in plasma renin activity, and plasma noradrenaline, aldosterone and cortisol concentrations in man. Clinical Endocrinology 14(3): 213-223, 1981

Effects of nifedipine on plasma renin activity plasma aldosterone and cortisol concentrations in patients with essential hypertension. Japanese Circulation Journal 50(6): 492, 1986

Acute and chronic effects of the aldosterone antagonist spironolactone and its main metabolite canrenone on plasma aldosterone concentration, plasma renin activity, serum electrolytes and on the excretion of aldosterone, fluid and electrolytes in rats. Naunyn-Schmiedeberg'sArchivesofPharmacology287Suppl:R52, 1975

Correlation between plasma aldosterone concentration and aldosterone urinary excretion in essential hypertension with normal, high and low plasma renin activity. Endokrynologia Polska 29(2): 131-138, 1978

Plasma renin activity, plasma renin substrate and urinary aldosterone excretion in the menstrual cycle in relation to the concentration of progesterone and oestrogens in the plasma. Acta Endocrinologica 71(3): 519-529, 1972

The effect of extremely high sodium intake on plasma renin activity, plasma aldosterone concentration, and urinary excretion of aldosterone metabolites. Journal of Laboratory and Clinical Medicine 93(5): 724-729, 1979

Increased carotid intimamedia thickness in hypertensive patients with a high aldosterone/plasma renin activity ratio and elevated aldosterone plasma concentration. Journal of Hypertension 26(7): 1500-1501, 2008

Increased carotid intima-media thickness in hypertensive patients with a high aldosterone/plasma renin activity ratio and elevated aldosterone plasma concentration. Journal of Hypertension 26(7): 1499-500; Author Reply 1500-1, 2008