+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Conversion of 7-ketolithocholic acid to ursodeoxycholic acid by human intestinal anaerobic microorganisms: interchangeability of chenodeoxycholic acid and ursodeoxycholic acid



Conversion of 7-ketolithocholic acid to ursodeoxycholic acid by human intestinal anaerobic microorganisms: interchangeability of chenodeoxycholic acid and ursodeoxycholic acid



Gastroenterologia Japonica 14(5): 417-424



Chenodeoxycholic acid, ursodeoxycholic acid and 7-ketolithocholic acid were incubated with human intestinal bacteria (source: 4 healthy males) at 37 degrees C for 72 hours in an anerobic condition. The bile acids of the products in culture medium were identified by three independent methods, thin layer chromatography, gas-liquid chromatography and GLC-mass spectrometry. Lithocholic acid, ursodeoxycholic acid and 7-ketolithocholic acid were observed in the culture of chenodeoxycholic acid. Lithocholic acid, chenodeoxycholic acid and 7-ketolithocholic acid were observed in the culture of ursodeoxycholic acid. Chenodeoxycholic acid and ursodeoxycholic acid were produced from 7-ketolithocholic acid. These data may suggest that chenodeoxycholic acid and ursodeoxycholic acid are interconvertible via 7-ketolithocholic acid by the mixed culture of human intestinal microorganisms under an anaerobic condition.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 039685606

Download citation: RISBibTeXText

PMID: 520764

DOI: 10.1007/bf02773728


Related references

Direct conversion of ursodeoxycholic acid to chenodeoxycholic acid by human intestinal microorganisms under the anaerobic condition. Nihon Shokakibyo Gakkai Zasshi 77(1): 113, 1980

Formation of ursodeoxycholic acid from chenodeoxycholic acid in the human colon: studies of the role of 7-ketolithocholic acid as an intermediate. Journal of Lipid Research 24(7): 841-853, 1983

Ursodeoxycholic acid, 7-ketolithocholic acid, and chenodeoxycholic acid are primary bile acids of the nutria (Myocastor coypus). Gastroenterology 90(3): 702-709, 1986

Ursodeoxycholic Acid, 7-Ketolithocholic Acid, and Chenodeoxycholic Acid Are Primary Bile Acids of the Nutria (Myocastor copus). Gastroenterology 90(3): 702-709, 1986

Chenodeoxycholic acid cdca ursodeoxycholic acid udca and 7 ketolithocholic acid 7klca are synthesized in the liver of the guinea pig. Gastroenterology 98(5 PART 2): A640, 1990

Ursodeoxycholic acid, chenodeoxycholic acid, and 7-ketolithocholic acid are primary bile acids of the guinea pig. Journal of Lipid Research 31(7): 1301-1306, 1990

In vitro transformation of chenodeoxycholic acid and ursodeoxycholic acid by human intestinal flora, with particular reference to the mutual conversion between the two bile acids. Journal of Lipid Research 22(5): 735-743, 1981

Competition in liver transport between chenodeoxycholic acid and ursodeoxycholic acid as a mechanism for ursodeoxycholic acid and its amidates' protection of liver damage induced by chenodeoxycholic acid. Digestive & Liver Disease 32(4): 318-328, 2000

Competition in liver transport between chenodeoxycholic acid and ursodeoxycholic acid as a mechanism for ursodeoxycholic acid and its amidates' protection of liver damage induced by chenodeoxycholic acid. Digestive and Liver Disease 32(4): 318-328, 2001

Efficacy and safety of ursodeoxycholic acid for dissolution of gallstone fragments comparison with the combination of ursodeoxycholic acid and chenodeoxycholic acid. Hepatology 14(6): 1136-1141, 1991

Efficacy and safety of a combination of chenodeoxycholic acid and ursodeoxycholic acid for gallstone dissolution: a comparison with ursodeoxycholic acid alone. Gastroenterology 96(1): 222-229, 1989

Transformation of chenodeoxycholic acid and ursodeoxycholic acid by human intestinal bacteria. Gastroenterology 77(5): 1068-1073, 1979

Mixed monolayer formation of bile acid mixtures chenodeoxycholic acid with ursodeoxycholic acid and cholic acid with beta muricholic acid. Journal of Colloid & Interface Science 149(1): 216-225, 1992

Stereocontrolled conversion of hyodeoxycholic acid into chenodeoxycholic acid and ursodeoxycholic acid. Journal of the Chemical Society Perkin Transactions I (1): 1-4, 1990

Epimerization of chenodeoxycholic acid to ursodeoxycholic acid by human intestinal lecithinase-lipase-negative Clostridia. Journal of Lipid Research 22(4): 652-658, 1981