Section 40
Chapter 39,692

Coronavirus infection induces H-2 antigen expression on oligodendrocytes and astrocytes

Suzumura, A.; Lavi, E.; Weiss, S.R.; Silberberg, D.H.

Science 232(4753): 991-993


ISSN/ISBN: 0036-8075
PMID: 3010460
DOI: 10.1126/science.3010460
Accession: 039691323

Infection of the central nervous system by mouse hepatitis virus strain A59, a murine neurotropic coronavirus, induces class I major histocompatibility complex antigens on mouse oligodendrocytes and astrocytes, cells that do not normally express these antigens on their surfaces. This induction, which occurs through soluble factors elaborated by infected glial cells, potentially allows immunocytes to interact with the glial cells and may play a critical role in the pathogenesis of virus-induced, immune-mediated demyelination in the central nervous system.

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