+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Cultured mammary carcinoma cells contain gonadotropin-releasing hormone-like immunoreactivity, GnRH binding sites and chorionic gonadotropin



Cultured mammary carcinoma cells contain gonadotropin-releasing hormone-like immunoreactivity, GnRH binding sites and chorionic gonadotropin



International Journal of Cancer 39(4): 498-501



Immunoperoxidase staining and radioimmunoassay were used to identify gonadotropin-releasing hormone (GnRH) and chorionic gonadotropin (hCG) in 4 mammary carcinoma cell lines. GnRH-like immunoreactivity was found in all cell lines; 2 lines also contained hCG. Binding of a GnRH agonist was demonstrated by radioreceptor assay in cultured mammary carcinoma cells. In cell column perfusion of the same cells, exogenous GnRH did not stimulate release of hCG.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 039714587

Download citation: RISBibTeXText

PMID: 3549577

DOI: 10.1002/ijc.2910390416


Related references

Changes in peripheral follicle stimulating hormone (FSH), luteinizing hormone (LH), inhibin, estradiol-17 beta , progesterone and testosterone levels before and after the administration of equine chorionic gonadotropin (eCG), human chorionic gonadotropin (hCG) and gonadotropin releasing hormone analogue (GnRH-A) in three cases of bovine gonadal hypoplasia (XY female). Journal of Reproduction and Development 46(6): 381-386, 2000

Inhibitory effect of pure 31-kilodalton bovine inhibin on gonadotropin-releasing hormone (GnRH)-induced up-regulation of GnRH binding sites in cultured rat anterior pituitary cells. Endocrinology 124(1): 363-368, 1989

Ovarian responses of seasonally anestrous ewes administered progesterone, PMS, HCG, and(or) GnRH Pregnant mare serum gonadotropin, human chorionic gonadotropin, gonadotropin releasing hormone. Theriogenology 19(3): 449-463, 1983

Cytochemical and cytophysiological studies of gonadotropin-releasing hormone (GnRH) target cells in the male rat pituitary: differential effects of androgens and corticosterone on GnRH binding and gonadotropin release. Endocrinology 117(1): 396-404, 1985

Effects of diacylglycerol and gonadotropin-releasing hormone on human chorionic gonadotropin release by cultured trophoblast cells. Placenta 13(3): 213-221, 1992

Regulation of gonadotropin mRNA levels in cultured rat pituitary cells by gonadotropin-releasing hormone (GnRH): role for Ca2+ and protein kinase C. Biochemistry 33(12): 3698-3704, 1994

Influence of continuous gonadotropin-releasing hormone (GnRH) agonist treatment on luteinizing hormone and testosterone secretion, the response to GnRH, and the testicular response to human chorionic gonadotropin in male rhesus monkeys. Journal of Clinical Endocrinology and Metabolism 58(2): 262-267, 1984

Ovarian 17-hydroxyprogesterone hyperresponsiveness to gonadotropin-releasing hormone (GnRH) agonist challenge in women with polycystic ovary syndrome is not mediated by luteinizing hormone hypersecretion: evidence from GnRH agonist and human chorionic gonadotropin stimulation testing. Journal of Clinical Endocrinology and Metabolism 81(11): 4103-4107, 1996

Detection of gonadotropin releasing hormone (GnRH) messenger RNA in the ovary and cloning of LH, chorionic gonadotropin (CG) receptor. Hokkaido Journal of Medical Science 66(6): 749-757, 1991

Use of a fluorescent gonadotropin releasing hormone antagonist in the analysis and purification of cells with gonadotropin releasing hormone binding sites. Journal of Cellular Biochemistry Suppl. (6): 171, 1982

Regulation of gonadotropin subunit messenger ribonucleic acid expression in gonadotropin-releasing hormone (GnRh)-deficient female rats: effects of GnRh, galanin, GnRh-associated peptide, neuropeptide- Y, and thyrotropin-releasing hormone. Biology of Reproduction 53(1): 1-7, 1995

Regulation of gonadotropin subunit messenger ribonucleic acid expression in gonadotropin-releasing hormone (GnRH)-deficient female rats: effects of GnRH, galanin, GnRH-associated peptide, neuropeptide-Y, and thyrotropin-releasing hormone. Biology of Reproduction 53(1): 1-7, 1995

Predictability of Sexual Maturation by Human Chorionic Gonadotropin (hCg) Test and Gonadotropin-Releasing Hormone (GnRh) Test in Prepubertal Boys with Idiopathic Growth Hormone Deficiency (Ghd): Diagnosis of Combined Gonadotropin Deficiency (Gnd) before Puberty. Clinical Pediatric Endocrinology 1(1): 21-25, 1992

Pregnancy establishment and maintenance after the administration of equine chorionic gonadotropin (eCG) associated or not with gonadotropin-releasing hormone (GnRH) after insemination in sheep. Animal Production Science 58(10): 1802-1806, 2018

Control of follicle development in cattle species using prostaglandin (PGF2alfa), gonadotropin releasing hormone (GnRH) and human chorionic gonadotropin (hCG). Large Animals Review 3(1): 5-13, 1997