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Determinants of coronavirus MHV pathogenesis are localized to 3' portions of the genome as determined by ribonucleic acid-ribonucleic acid recombination



Determinants of coronavirus MHV pathogenesis are localized to 3' portions of the genome as determined by ribonucleic acid-ribonucleic acid recombination



Laboratory Investigation; a Journal of Technical Methods and Pathology 62(5): 570-578



Recombinant viruses derived from coronaviruses mouse hepatitis virus strains JHM and A59, were used to map biologic properties of the virus to viral genes. The 3' portion (about 25%) of the viral genome, including the genes coding for all of the structural proteins, controls biologic properties such as organ tropism of the virus, pattern of the virus-induced central nervous system pathology in mice, plaque morphology, and virus yield in tissue culture.

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Accession: 039778867

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PMID: 2160561


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Determinants of coronavirus mhv pathogenesis are localized to 3' portions of the genome as determined by rna recombinant rna. Laboratory Investigation 62(5): 570-578, 1990

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