+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Determination of monoamine and monoamine metabolites in the human brain: post mortem studies in a group of suicides and in a control group



Determination of monoamine and monoamine metabolites in the human brain: post mortem studies in a group of suicides and in a control group



Acta Psychiatrica Scandinavica 53(1): 7-20



Different nuclei and regions of the brain from patients who had committed suicide and from controls were analysed for their content of monoamine and monoamine metabolites. There was a post mortem breakdown of 5-hydroxyindoleacetic acid (5-HIAA) which could be correlated to the time elapsed between the occurrence of death and autopsy. Homovanillic acid (HVA) and the monoamines did not decrease post mortem during the time observed (6-148 hours). There was no significant correlation between age and chemical variables in this investigation. There were no significant group differences between suicides and controls concerning dopamine, noradrenaline, 5-hydroxytryptamine, and HVA, 5-HIAA levels were significantly lower in the suicide group in six out of eight parts of the brain investigated. It was, however, also demonstrated that there was a longer time elapse between the occurrence of death and autopsy in the suicide group. The suicides came on average 48 hours later to autopsy than the controls. As there was a post mortem decrease of 5-HIAA, this time variable had to be kept constant when group differences were analysed. When the influence of this time variable was eliminated there were no longer any differences between suicides and controls. According to this investigation, there seem to be no differences in levels of monoamines and their metabolites between suicides and controls.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 039783861

Download citation: RISBibTeXText

PMID: 1251756

DOI: 10.1111/j.1600-0447.1976.tb00054.x


Related references

Topographic immunocytochemical mapping of monoamine oxidase-A, monoamine oxidase-B and tyrosine hydroxylase in human post mortem brain stem. Neuroscience 26(3): 791-802, 1988

Monoamine oxidase activity during (--)-deprenil therapy: human brain post-mortem studies. Advances in Biochemical Psychopharmacology 19: 377-382, 1978

Monoamine fluorescence histochemistry of human post mortem brain. Brain Research 63: 231-247, 1973

Cocaine use decreases monoamine levels in post mortem human brain. Society for Neuroscience Abstracts 21(1-3): 721, 1995

Post-mortem fluorescence histochemistry of monoamine neuron systems in the human brain: a new approach in the search for a neuropathology of schizophrenia. Journal of Psychiatric Research 11: 199-203, 1974

Effect of ischemia on monoamine metabolism. Brain monoamine metabolites in cerebrospinal fluid of patients with recent cerebral infarction. Neuropatologia Polska 20(1-2): 97-105, 1982

Comparative study of phenothiazine derivatives on monoamine metabolism--direct correlation between the concentrations of drugs and monoamine metabolites in the brain. Journal of Pharmacology and Experimental Therapeutics 240(3): 959-965, 1987

Phenothiazine derivatives and intracerebral monoamine metabolism: Application of direct correlation analysis between the levels of drugs and monoamine metabolites in rat brain. Nichidai Igaku Zasshi 53(9): 701-709, 1994

Effect of aging on lazabemide binding, monoamine oxidase activity and monoamine metabolites in human frontal cortex. Journal Of Neural Transmission General Section. 101(1-3): 83-94, 1995

Changes in monoamine and monoamine metabolites in the nucleus accumbens and locomotor activity caused by p-chloroamphetamine: studies with intracerebral dialysis in freely moving rats. Seishin Shinkeigaku Zasshi 95(7): 507-522, 1993

Pharmacokinetics of oral moclobemide in healthy human subjects and effects on monoamine oxidase activity in platelets and excretion of urine monoamine metabolites. European Journal of Clinical Pharmacology 28(1): 89-96, 1985

Seasonal and circadian monoamine variations in human brains examined post mortem. Acta Psychiatrica Scandinavica. Supplementum 280: 75-85, 1980

Concentrations of cerebrospinal fluid monoamine metabolites in suicides. Psychological Reports 68(1): 146, 1991

Simultaneous liquid chromatographic determination of seventeen of the major monoamine neurotransmitters precursors and metabolites ii. assessment of human brain and cerebrospinal fluid concentrations. Journal of Chromatography Biomedical Applications 415(2): 275-288, 1987

Studies on monoamine oxidase. 5. Enzymic differences in the monoamine oxidases in the brain and liver. Nihon Yakurigaku Zasshi. Folia Pharmacologica Japonica 64(4): 393-398, 1968